Editing Adrenal cortex (section)

=== Glucocorticoids ===
{{Main|Glucocorticoids}}
Glucocorticoids are produced mainly in the [[zona fasciculata]].<ref name=":0" />
 
Glucocorticoids are steroid hormones that are necessary for life.<ref>{{Cite journal |last1=Cain |first1=Derek W. |last2=Cidlowski |first2=John A. |date=2017-02-13 |title=Immune regulation by glucocorticoids |journal=Nature Reviews Immunology |language=en |volume=17 |issue=4 |pages=233–247 |doi=10.1038/nri.2017.1 |issn=1474-1733 |pmc=9761406 |pmid=28192415}}</ref> They play a role in numerous physiological responses including; metabolism, immune response, mood, cognitive functions, cardiovascular function, and reproduction.<ref>{{Cite journal |last1=Timmermans |first1=Steven |last2=Souffriau |first2=Jolien |last3=Libert |first3=Claude |date=2019-07-04 |title=A General Introduction to Glucocorticoid Biology |journal=Frontiers in Immunology |language=English |volume=10 |page=1545 |doi=10.3389/fimmu.2019.01545 |doi-access=free |issn=1664-3224 |pmc=6621919 |pmid=31333672}}</ref> Glucocorticoids are also widely prescribed as medication to treat numerous conditions such as autoimmune diseases and lymphoproliferative diseases. <ref>{{Cite journal |last1=CHARMANDARI |first1=EVANGELIA |last2=KINO |first2=TOMOSHIGE |last3=CHROUSOS |first3=GEORGE P. |date=June 2004 |title=Glucocorticoids and Their Actions: An Introduction |url=https://login.libaccess.sjlibrary.org/login?qurl=https://doi.org%2f10.1196%2fannals.1321.001 |journal=Annals of the New York Academy of Sciences |language=en |volume=1024 |issue=1 |pages=1–8 |doi=10.1196/annals.1321.001 |pmid=15265770 |bibcode=2004NYASA1024....1C |issn=0077-8923|url-access=subscription }}</ref> The main glucocorticoid in humans is cortisol.<ref>{{Cite journal |last1=Manenschijn |first1=Laura |last2=van den Akker |first2=Erica L. T. |last3=Lamberts |first3=Steven W. J. |last4=van Rossum |first4=Elisabeth F. C. |date=October 2009 |title=Clinical features associated with glucocorticoid receptor polymorphisms. An overview |url=https://pubmed.ncbi.nlm.nih.gov/19906240/ |journal=Annals of the New York Academy of Sciences |volume=1179 |pages=179–198 |doi=10.1111/j.1749-6632.2009.05013.x |issn=1749-6632 |pmid=19906240}}</ref>