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Amputation
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===Circulatory disorders=== * [[Diabetes|Diabetic]] vasculopathy * [[Sepsis]] with peripheral necrosis * [[Peripheral artery disease]] which can lead to [[gangrene]] * A severe [[deep vein thrombosis]] ([[phlegmasia cerulea dolens]]) can cause [[compartment syndrome]] and gangrene<ref name=Compartment>{{cite journal | vauthors = Abdul W, Hickey B, Wilson C | title = Lower extremity compartment syndrome in the setting of iliofemoral deep vein thrombosis, phlegmasia cerulea dolens and factor VII deficiency | journal = BMJ Case Reports | volume = 2016 | date = April 2016 | pages = bcr2016215078 | pmid = 27113791 | pmc = 4854131 | doi = 10.1136/bcr-2016-215078 }}</ref>
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