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Angiotensin-converting enzyme
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==History== The enzyme was reported by Leonard T. Skeggs Jr. in 1956.<ref name = "Skeggs_1956">{{cite journal | vauthors = Skeggs LT, Kahn JR, Shumway NP | title = The preparation and function of the hypertensin-converting enzyme | journal = The Journal of Experimental Medicine | volume = 103 | issue = 3 | pages = 295β299 | date = March 1956 | pmid = 13295487 | pmc = 2136590 | doi = 10.1084/jem.103.3.295 }}</ref> The crystal structure of human testis ACE was solved in the year 2002 by Ramanathan Natesh in the lab of K. Ravi Acharya in collaboration with Sylva Schwager and Edward Sturrock who purified the protein.<ref name="Natesh_2003">{{cite journal | vauthors = Natesh R, Schwager SL, Sturrock ED, Acharya KR | title = Crystal structure of the human angiotensin-converting enzyme-lisinopril complex | journal = Nature | volume = 421 | issue = 6922 | pages = 551β554 | date = January 2003 | pmid = 12540854 | doi = 10.1038/nature01370 | s2cid = 4137382 | bibcode = 2003Natur.421..551N | url = http://www.pharmpharm.ru/jour/article/view/271 | access-date = 22 May 2020 | archive-date = 26 November 2022 | archive-url = https://web.archive.org/web/20221126081429/https://www.pharmpharm.ru/jour/article/view/271 | url-status = live | url-access = subscription }}</ref> It is located mainly in the capillaries of the lungs but can also be found in [[Endothelial cell|endothelial]] and kidney [[epithelial cell]]s.<ref name="isbn0-323-04527-8">{{cite book | author = Kierszenbaum, Abraham L. | title = Histology and cell biology: an introduction to pathology | publisher = Mosby Elsevier | year = 2007 | isbn = 978-0-323-04527-8 }}</ref>
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