Editing B cell (section)

== Epigenetics ==
A study that investigated the [[methylome]] of B cells along their differentiation cycle, using [[Whole genome bisulfite sequencing|whole-genome bisulfite sequencing]] (WGBS), showed that there is a hypomethylation from the earliest stages to the most differentiated stages. The largest methylation difference is between the stages of germinal center B cells and memory B cells. Furthermore, this study showed that there is a similarity between B cell tumors and long-lived B cells in their [[DNA methylation]] signatures.<ref>{{cite journal | vauthors = Kulis M, Merkel A, Heath S, Queirós AC, Schuyler RP, Castellano G, Beekman R, Raineri E, Esteve A, Clot G, Verdaguer-Dot N, Duran-Ferrer M, Russiñol N, Vilarrasa-Blasi R, Ecker S, Pancaldi V, Rico D, Agueda L, Blanc J, Richardson D, Clarke L, Datta A, Pascual M, Agirre X, Prosper F, Alignani D, Paiva B, Caron G, Fest T, Muench MO, Fomin ME, Lee ST, Wiemels JL, Valencia A, Gut M, Flicek P, Stunnenberg HG, Siebert R, Küppers R, Gut IG, Campo E, Martín-Subero JI | display-authors = 6 | title = Whole-genome fingerprint of the DNA methylome during human B cell differentiation | journal = Nature Genetics | volume = 47 | issue = 7 | pages = 746–756 | date = July 2015 | pmid = 26053498 | pmc = 5444519 | doi = 10.1038/ng.3291 }}</ref>