Editing CYP3A4 (section)

==Turnover==
Estimates of the [[protein turnover|turnover]] rate of human CYP3A4 vary widely. For hepatic CYP3A4, ''in vivo'' methods yield estimates of the enzyme [[Biological half-life|half-life]] mainly in the range of 70 to 140 hours, whereas ''in vitro'' methods give estimates from 26 to 79 hours.<ref name = "Yang"/> Turnover of gut CYP3A4 is likely to be a function of the rate of [[enterocyte]] [[cell cycle|renewal]]; an indirect approach based on the recovery of activity following exposure to grapefruit juice yields measurements in the 12- to 33-hour range.<ref name = "Yang">{{cite journal | vauthors = Yang J, Liao M, Shou M, Jamei M, Yeo KR, Tucker GT, Rostami-Hodjegan A | title = Cytochrome p450 turnover: regulation of synthesis and degradation, methods for determining rates, and implications for the prediction of drug interactions | journal = Current Drug Metabolism | volume = 9 | issue = 5 | pages = 384–94 | date = June 2008 | pmid = 18537575 | doi = 10.2174/138920008784746382 }}</ref>