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Calmodulin
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==== Role in short-term and long-term memory ==== [[Ca2+/calmodulin-dependent protein kinase II|Ca<sup>2+</sup>/calmodulin-dependent protein kinase II]] (CaMKII) plays a crucial role in a type of synaptic plasticity known as [[long-term potentiation]] (LTP) which requires the presence of calcium/calmodulin. CaMKII contributes to the [[phosphorylation]] of an [[AMPA receptor]] which increases the sensitivity of AMPA receptors.<ref name="Lledo-1995">{{cite journal | vauthors = Lledo PM, Hjelmstad GO, Mukherji S, Soderling TR, Malenka RC, Nicoll RA | title = Calcium/calmodulin-dependent kinase II and long-term potentiation enhance synaptic transmission by the same mechanism | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 92 | issue = 24 | pages = 11175β9 | date = November 1995 | pmid = 7479960 | pmc = 40594 | doi = 10.1073/pnas.92.24.11175 | bibcode = 1995PNAS...9211175L | doi-access = free }}</ref> Furthermore, research shows that inhibiting CaMKII interferes with LTP.<ref name="Lledo-1995" />
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