Editing Cannabinoid receptor (section)

== Ligands ==
{{further|Cannabinoid receptor type 1#Ligands|Cannabinoid receptor type 2#Ligands}}

Binding affinity and selectivity of cannabinoid ligands:
{| class="wikitable sortable" style="font-size: smaller; text-align: center; width: auto;"
|-
! style="width: 12em"|
! CB<sub>1</sub> affinity (K<sub>i</sub>)
! Efficacy towards CB<sub>1</sub>
! CB<sub>2</sub> affinity (K<sub>i</sub>)
! Efficacy towards CB<sub>2</sub>
! Type
! References

|-
! '''[[Anandamide]]'''
| 78nM
| Partial agonist
| 370nM
| ?
| Endogenous
|
|-
! [[N-Arachidonoyl dopamine]]
| ?
| Agonist
| ?
| ?
| Endogenous
|
|-
! [[2-Arachidonoylglycerol]]
| ?
| Full agonist
| ?
| ?
| Endogenous

|
|-
! [[2-Arachidonyl glyceryl ether]]
| 21 nM
| Full agonist
| 480nM
| Full agonist
| Endogenous
|
|-
!  '''[[Δ-9-Tetrahydrocannabinol]]'''
|  10nM
|  Partial agonist
|  24nM
|  Partial agonist
|  Phytogenic
| <ref name="whoa">{{cite web|title=PDSP Database - UNC|url=http://pdsp.med.unc.edu/pdsp.php?|access-date=11 June 2013|url-status=dead|archive-url=https://web.archive.org/web/20131108013656/http://pdsp.med.unc.edu/pdsp.php|archive-date=8 November 2013}}</ref>
|-
! [[EGCG]]
| 33,600 nM
| Agonist
| >50,000 nM
| ?
| Phytogenic
|<ref name="ecgc">{{cite journal | vauthors = Korte G, Dreiseitel A, Schreier P, Oehme A, Locher S, Geiger S, Heilmann J, Sand PG | display-authors = 6 | title = Tea catechins' affinity for human cannabinoid receptors | journal = Phytomedicine | volume = 17 | issue = 1 | pages = 19–22 | date = January 2010 | pmid = 19897346 | doi = 10.1016/j.phymed.2009.10.001 }}</ref>
|-
! [[Yangonin]]
| 720 nM
| ?
|  >10,000 nM
| ?
| Phytogenic
| <ref>{{cite journal | vauthors = Ligresti A, Villano R, Allarà M, Ujváry I, Di Marzo V | title = Kavalactones and the endocannabinoid system: the plant-derived yangonin is a novel CB₁ receptor ligand | journal = Pharmacological Research | volume = 66 | issue = 2 | pages = 163–9 | date = August 2012 | pmid = 22525682 | doi = 10.1016/j.phrs.2012.04.003 }}</ref>
|- 
! [[AM-1221]]
|  52.3nM
|  Agonist
|  0.28nM
|  Agonist
|  Synthetic
| <ref name="dude">{{Ref patent2 |country= WO |number= 200128557 |status= granted |title= Cannabimimetic indole derivatives |pubdate= 2001-04-26 |gdate= 2001-06-07 |pridate= 1999-10-18 |inventor= [[Makriyannis A]], Deng H }}</ref>
|-
! [[AM-1235]]
|  1.5nM
|  Agonist
|  20.4nM
|  Agonist
|  Synthetic
| <ref name="like">{{Ref patent2 | country = US | number = 7241799 | status = granted | title = Cannabimimetic indole derivatives | pubdate = 2004-11-05 | gdate = 2007-07-10 | pridate= 2004-11-05 | inventor = Makriyannis A, Deng H | assign1= }}</ref>
|-
! [[AM-2232]]
|  0.28nM
|  Agonist
|  1.48nM
|  Agonist
|  Synthetic
|  <ref name="like"/>
|-
! [[UR-144]]
|  150nM
|  Full agonist
|  1.8nM
|  Full agonist
|  Synthetic
| <ref name="myhandsareamazing">{{cite journal | vauthors = Frost JM, Dart MJ, Tietje KR, Garrison TR, Grayson GK, Daza AV, El-Kouhen OF, Yao BB, Hsieh GC, Pai M, Zhu CZ, Chandran P, Meyer MD | display-authors = 6 | title = Indol-3-ylcycloalkyl ketones: effects of N1 substituted indole side chain variations on CB(2) cannabinoid receptor activity | journal = Journal of Medicinal Chemistry | volume = 53 | issue = 1 | pages = 295–315 | date = January 2010 | pmid = 19921781 | doi = 10.1021/jm901214q }}</ref>
|-
! [[JWH-007]]
|  9.0nM
|  Agonist
|  2.94nM
|  Agonist
|  Synthetic
|  <ref name="Aung_2000">{{cite journal | vauthors = Aung MM, Griffin G, Huffman JW, Wu M, Keel C, Yang B, Showalter VM, Abood ME, Martin BR | display-authors = 6 | title = Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB(1) and CB(2) receptor binding | journal = Drug and Alcohol Dependence | volume = 60 | issue = 2 | pages = 133–40 | date = August 2000 | pmid = 10940540 | doi = 10.1016/S0376-8716(99)00152-0 }}</ref>
|-
! [[JWH-015]]
|  383nM
|  Agonist
|  13.8nM
|  Agonist
|  Synthetic
| <ref name="Aung_2000"/>
|-
! [[JWH-018]]
|  9.00 ± 5.00 nM
|  Full agonist
|  2.94 ± 2.65 nM
|  Full agonist
|  Synthetic
| <ref name="Aung_2000"/>
|-
|}