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Cooperativity
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===Supramultiplicativity=== Several authors have reported the existence of supramultiplicative behavior in signaling cascades <ref name="altszylerUltrasens2014">{{cite journal | vauthors = Altszyler E, Ventura A, Colman-Lerner A, Chernomoretz A | title = Impact of upstream and downstream constraints on a signaling module's ultrasensitivity | journal = Physical Biology | volume = 11 | issue = 6 | pages = 066003 | date = October 2014 | pmid = 25313165 | pmc = 4233326 | doi = 10.1088/1478-3975/11/6/066003 | bibcode = 2014PhBio..11f6003A }}</ref><ref name="racz2008">{{cite journal | vauthors = RΓ‘cz E, Slepchenko BM | title = On sensitivity amplification in intracellular signaling cascades | journal = Physical Biology | volume = 5 | issue = 3 | pages = 036004 | date = July 2008 | pmid = 18663279 | pmc = 2675913 | doi = 10.1088/1478-3975/5/3/036004 | bibcode = 2008PhBio...5c6004R }}</ref> (i.e. the ultrasensitivity of the combination of layers is higher than the product of individual ultrasensitivities), but in many cases the ultimate origin of supramultiplicativity remained elusive. Altszyler et al. (2017)<ref name="Altszyler_2017"/> framework naturally suggested a general scenario where supramultiplicative behavior could take place. This could occur when, for a given module, the corresponding Hill's input working range was located in an input region with local ultrasensitivities higher than the global ultrasensitivity of the respective dose-response curve.
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