Editing DNA-binding protein (section)

=== Manipulating the interactions ===
The protein–DNA interactions can be modulated using stimuli like ionic strength of the buffer, macromolecular crowding,<ref name="explore" /> temperature, pH and electric field. This can lead to reversible dissociation/association of the protein–DNA complex.<ref>{{cite journal | vauthors = Hianik T, Wang J | year = 2009 | title = Electrochemical Aptasensors – Recent Achievements and Perspectives | journal = Electroanalysis | volume = 21 | issue = 11| pages = 1223–1235 | doi = 10.1002/elan.200904566 }}</ref><ref>{{cite journal | vauthors = Gosai A | display-authors = etal | year = 2016 | title = Electrical Stimulus Controlled Binding/Unbinding of Human Thrombin-Aptamer Complex | pmc = 5118750 | journal = Sci. Rep. | volume = 6 | page = 37449 | doi = 10.1038/srep37449 | pmid = 27874042 | bibcode = 2016NatSR...637449G }}</ref>