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Digitoxin
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==History== The first description of the use of [[Digitalis purpurea|foxglove]] dates back to 1775.<ref>{{cite book | url = https://archive.org/details/b21517356 | title = An Account of the Foxglove and Some of its Medical Uses: With Practical Remarks on Dropsy and other Diseases | publisher = Classics of Medicine Library | last = Withering | first = William | name-list-style = vanc | year = 1785 }}</ref> For quite some time, the active compound was not isolated. [[Oswald Schmiedeberg]] was able to obtain a pure sample in 1875. The modern therapeutic use of this molecule was made possible by the works of the pharmacist and the French chemist [[Claude-Adolphe Nativelle]] (1812β1889). The first structural analysis was done by [[Adolf Otto Reinhold Windaus]] in 1925, but the full structure with an exact determination of the sugar groups was not accomplished until 1962.<ref>{{cite journal | vauthors = Diefenbach WC, Meneely JK | title = Digitoxin; a critical review | journal = The Yale Journal of Biology and Medicine | volume = 21 | issue = 5 | pages = 421β31 | date = May 1949 | pmid = 18127991 | pmc = 2598854 }}</ref><ref>{{cite book | url = https://books.google.com/books?id=mYQxRY9umjcC&pg=PA107 | pages = 107 | title = Drug discovery: A history | isbn = 978-0-471-89980-8 | last = Sneader | first = Walter | name-list-style = vanc | year = 2005| publisher = Wiley }}</ref>
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