Editing Forward genetics (section)

== History ==
Gregor Mendel experimented with pea plant phenotypes and published his conclusions about genes and inheritance in 1865.<ref name="Brown_2018" /> Around the early 1900s [[Thomas Hunt Morgan]] was mutating ''Drosophila'' using radium and attempting to find heritable mutations.<ref>{{Cite news  | first = Vivien | last = Hamilton | name-list-style = vanc |url=https://www.sciencehistory.org/distillations/magazine/the-secrets-of-life |title=The Secrets of Life|date=2016-07-19|work=Science History Institute|access-date=2018-09-25 }}</ref> Alfred Sturtevant later began mapping genes of ''Drosophila'' with mutations they had been following.<ref>{{Cite web|url=https://www.genome.gov/12011238/an-overview-of-the-human-genome-project/|title=An Overview of the Human Genome Project|website=National Human Genome Research Institute (NHGRI)|language=en-US|access-date=2018-09-25}}</ref> In the 1990s forward genetics methods were utilized to better understand ''Drosophila'' genes significant to development from embryo to adult fly.<ref name=":2">{{Cite book|title=Developmental Biology|last=Gilbert|first=Scott | name-list-style = vanc |publisher=Sinauer Associates Inc.|year=2014|isbn=978-0-87893-978-7|location=Sutherland, MA}}</ref> In 1995 the Nobel Prize went to Christiane Nüsslein, Edward Lewis, and Eris Wieschaus for their work in developmental genetics.<ref name=":2" /> The human genome was mapped and the sequence was published in [[Human Genome Project|2003]].<ref>{{Cite web|url=https://www.genome.gov/12011238/an-overview-of-the-human-genome-project/|title=An Overview of the Human Genome Project|website=National Human Genome Research Institute (NHGRI) |access-date=2018-09-25}}</ref> The ability to identify genes that contribute to Mendelian disorders has improved since 1990 as a result of advances in genetics and technology.<ref name="Stearns_2008" />