Editing GABAA receptor (section)

=== Examples ===
* Orthosteric agonists: [[GABA]], [[gaboxadol]], [[isoguvacine]], [[muscimol]], [[progabide]], [[beta-alanine]],<ref name="Mori 191–200">{{cite journal | vauthors = Mori M, Gähwiler BH, Gerber U | title = Beta-alanine and taurine as endogenous agonists at glycine receptors in rat hippocampus in vitro | journal = The Journal of Physiology | volume = 539 | issue = Pt 1 | pages = 191–200 | date = February 2002 | pmid = 11850512 | pmc = 2290126 | doi = 10.1113/jphysiol.2001.013147 }}</ref><ref name="Horikoshi 97–105">{{cite journal | vauthors = Horikoshi T, Asanuma A, Yanagisawa K, Anzai K, Goto S | title = Taurine and beta-alanine act on both GABA and glycine receptors in Xenopus oocyte injected with mouse brain messenger RNA | journal = Brain Research | volume = 464 | issue = 2 | pages = 97–105 | date = September 1988 | pmid = 2464409 | doi = 10.1016/0169-328x(88)90002-2 }}</ref> [[taurine]],<ref name="Horikoshi 97–105"/><ref name="Mori 191–200"/> [[piperidine-4-sulfonic acid]] (partial agonist).
* Orthosteric antagonists: [[bicuculline]], [[gabazine]].
* Positive allosteric modulators: [[abecarnil]],<ref>{{Cite journal |last1=Dn |first1=Stephens |last2=Hh |first2=Schneider |last3=W |first3=Kehr |last4=Js |first4=Andrews |last5=Kj |first5=Rettig |last6=L |first6=Turski |last7=R |first7=Schmiechen |last8=Jd |first8=Turner |last9=Lh |first9=Jensen |last10=En |first10=Petersen |date=April 1990 |title=Abecarnil, a metabolically stable, anxioselective beta-carboline acting at benzodiazepine receptors |url=https://pubmed.ncbi.nlm.nih.gov/1970361/ |journal=The Journal of Pharmacology and Experimental Therapeutics |language=en |volume=253 |issue=1 |pages=334–343 |doi=10.1016/S0022-3565(25)12465-8 |issn=0022-3565 |pmid=1970361}}</ref> [[Abecarnil|azocarnil]]<ref>{{Cite journal |last1=Maleeva |first1=Galyna |last2=Nin-Hill |first2=Alba |last3=Wirth |first3=Ulrike |last4=Rustler |first4=Karin |last5=Ranucci |first5=Matteo |last6=Opar |first6=Ekin |last7=Rovira |first7=Carme |last8=Bregestovski |first8=Piotr |last9=Zeilhofer |first9=Hanns Ulrich |last10=König |first10=Burkhard |last11=Alfonso-Prieto |first11=Mercedes |last12=Gorostiza |first12=Pau |date=2024-10-09 |title=Light-Activated Agonist-Potentiator of GABA A Receptors for Reversible Neuroinhibition in Wildtype Mice |journal=Journal of the American Chemical Society |volume=146 |issue=42 |pages=28822–28831 |language=en |doi=10.1021/jacs.4c08446 |pmid=39383450 |issn=0002-7863|pmc=11503767 |bibcode=2024JAChS.14628822M }}</ref> ([[Photoswitch|photoswitchable]]), [[barbiturate]]s, [[benzodiazepine]]s, certain [[carbamates]] (e.g., [[carisoprodol]], [[meprobamate]], [[lorbamate]]), [[honokiol]], [[magnolol]], [[baicalin]], [[baicelin]], [[thienodiazepine]]s, [[alcohol (drug)|alcohol]] ([[ethanol]]), [[etomidate]], [[glutethimide]], [[kavalactone]]s,<ref name="Hunter">{{cite journal |author=Hunter, A | title=Kava (Piper methysticum) back in circulation | journal=Australian Centre for Complementary Medicine |volume=25 | issue=7 | year=2006 | page=529}}</ref> [[meprobamate]], [[quinazolinone]]s (e.g., [[methaqualone]], [[etaqualone]], [[diproqualone]]), [[neuroactive steroid]]s,<ref name="neuroactive_steroid">(a) {{cite journal | vauthors = Herd MB, Belelli D, Lambert JJ | title = Neurosteroid modulation of synaptic and extrasynaptic GABA(A) receptors | journal = Pharmacology & Therapeutics | volume = 116 | issue = 1 | pages = 20–34 | date = October 2007 | pmid = 17531325 | doi = 10.1016/j.pharmthera.2007.03.007 | url = http://www.journals.elsevier.com/pharmacology-and-therapeutics | arxiv = 1607.02870 }}<br/>(b) {{cite journal | vauthors = Hosie AM, Wilkins ME, da Silva HM, Smart TG | title = Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites | journal = Nature | volume = 444 | issue = 7118 | pages = 486–9 | date = November 2006 | pmid = 17108970 | doi = 10.1038/nature05324 | bibcode = 2006Natur.444..486H | s2cid = 4382394 }}<br/>(c) {{cite journal | vauthors = Agís-Balboa RC, Pinna G, Zhubi A, Maloku E, Veldic M, Costa E, Guidotti A | title = Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 103 | issue = 39 | pages = 14602–7 | date = September 2006 | pmid = 16984997 | pmc = 1600006 | doi = 10.1073/pnas.0606544103 | bibcode = 2006PNAS..10314602A | doi-access = free }}<br/>(d) {{cite journal | vauthors = Akk G, Shu HJ, Wang C, Steinbach JH, Zorumski CF, Covey DF, Mennerick S | title = Neurosteroid access to the GABAA receptor | journal = The Journal of Neuroscience | volume = 25 | issue = 50 | pages = 11605–13 | date = December 2005 | pmid = 16354918 | pmc = 6726021 | doi = 10.1523/JNEUROSCI.4173-05.2005 }}<br/>(e) {{cite journal | vauthors = Belelli D, Lambert JJ | title = Neurosteroids: endogenous regulators of the GABA(A) receptor | journal = Nature Reviews. Neuroscience | volume = 6 | issue = 7 | pages = 565–575 | date = July 2005 | pmid = 15959466 | doi = 10.1038/nrn1703 | s2cid = 12596378 }}<br/>(f) {{cite journal | vauthors = Pinna G, Costa E, Guidotti A | title = Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake | journal = Psychopharmacology | volume = 186 | issue = 3 | pages = 362–372 | date = June 2006 | pmid = 16432684 | doi = 10.1007/s00213-005-0213-2 | s2cid = 7799814 }}<br/>(g) {{cite journal | vauthors = Dubrovsky BO | title = Steroids, neuroactive steroids and neurosteroids in psychopathology | journal = Progress in Neuro-Psychopharmacology & Biological Psychiatry | volume = 29 | issue = 2 | pages = 169–192 | date = February 2005 | pmid = 15694225 | doi = 10.1016/j.pnpbp.2004.11.001 | s2cid = 36197603 }}<br/>(h) {{cite journal | vauthors = Mellon SH, Griffin LD | title = Neurosteroids: biochemistry and clinical significance | journal = Trends in Endocrinology and Metabolism | volume = 13 | issue = 1 | pages = 35–43 | year = 2002 | pmid = 11750861 | doi = 10.1016/S1043-2760(01)00503-3 | s2cid = 11605131 }}<br/>(i) {{cite journal | vauthors = Puia G, Santi MR, Vicini S, Pritchett DB, Purdy RH, Paul SM, Seeburg PH, Costa E | title = Neurosteroids act on recombinant human GABAA receptors | journal = Neuron | volume = 4 | issue = 5 | pages = 759–765 | date = May 1990 | pmid = 2160838 | doi = 10.1016/0896-6273(90)90202-Q | s2cid = 12626366 }}<br/>(j) {{cite journal | vauthors = Majewska MD, Harrison NL, Schwartz RD, Barker JL, Paul SM | title = Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor | journal = Science | volume = 232 | issue = 4753 | pages = 1004–7 | date = May 1986 | pmid = 2422758 | doi = 10.1126/science.2422758 | url = https://zenodo.org/record/1230988 | bibcode = 1986Sci...232.1004D }}<br/>(k) {{cite book |vauthors=Reddy DS, Rogawski MA | chapter = Neurosteroids — Endogenous Regulators of Seizure Susceptibility and Role in the Treatment of Epilepsy |veditors=Noebels JL, Avoli M, Rogawski MA |title = Jasper's Basic Mechanisms of the Epilepsies [Internet] |edition=4th |publisher=National Center for Biotechnology Information (US) | date = 2012 | chapter-url = https://www.ncbi.nlm.nih.gov/books/NBK98218/ |id=NBK98218 |display-editors=etal | pmid = 22787590 }}</ref> [[Niacin (nutrient)|niacin]]/[[niacinamide]],<ref>{{cite journal| vauthors = Toraskar M, Singh PR, Neve S |title=STUDY OF GABAERGIC AGONISTS|journal=Deccan Journal of Pharmacology|year=2010|volume=1|issue=2|pages=56–69|url=http://www.ijdpls.com/uploaded/journal_files/120402040442.pdf|access-date=2013-02-12|archive-url=https://web.archive.org/web/20131016082147/http://www.ijdpls.com/uploaded/journal_files/120402040442.pdf|archive-date=2013-10-16|url-status=dead}}</ref> [[nonbenzodiazepine]]s (e.g., [[zolpidem]], [[eszopiclone]]), [[propofol]], [[stiripentol]],<ref>{{cite journal | vauthors = Fisher JL | title = The anti-convulsant stiripentol acts directly on the GABA(A) receptor as a positive allosteric modulator | journal = Neuropharmacology | volume = 56 | issue = 1 | pages = 190–7 | date = January 2009 | pmid = 18585399 | pmc = 2665930 | doi = 10.1016/j.neuropharm.2008.06.004 }}</ref> [[theanine]],{{citation needed|date=November 2017}} [[valerenic acid]], [[Volatile anaesthetic|volatile/inhaled]] [[anesthetic]]s, [[lanthanum]],<ref>{{cite journal | vauthors = Boldyreva AA | title = Lanthanum potentiates GABA-activated currents in rat pyramidal neurons of CA1 hippocampal field | journal = Bulletin of Experimental Biology and Medicine | volume = 140 | issue = 4 | pages = 403–5 | date = October 2005 | pmid = 16671565 | doi = 10.1007/s10517-005-0503-z | s2cid = 13179025 }}</ref> [[riluzole]],<ref name="pmid11804616">{{cite journal | vauthors = He Y, Benz A, Fu T, Wang M, Covey DF, Zorumski CF, Mennerick S | title = Neuroprotective agent riluzole potentiates postsynaptic GABA(A) receptor function | journal = Neuropharmacology | volume = 42 | issue = 2 | pages = 199–209 | date = February 2002 | pmid = 11804616 | doi = 10.1016/s0028-3908(01)00175-7 | s2cid = 24194421 }}</ref> and [[menthol]].<ref>{{cite journal | pmc=4243856 | date=2014 | last1=Lau | first1=B. K. | last2=Karim | first2=S. | last3=Goodchild | first3=A. K. | last4=Vaughan | first4=C. W. | last5=Drew | first5=G. M. | title=Menthol enhances phasic and tonic GABAA receptor-mediated currents in midbrain periaqueductal grey neurons | journal=British Journal of Pharmacology | volume=171 | issue=11 | pages=2803–13 | doi=10.1111/bph.12602 | pmid=24460753 }}</ref>
* Negative allosteric modulators: [[flumazenil]], [[Ro15-4513]], [[sarmazenil]], [[pregnenolone sulfate]], [[amentoflavone]], and [[zinc]].<ref name="pmid12640458">{{cite journal | vauthors = Hosie AM, Dunne EL, Harvey RJ, Smart TG | title = Zinc-mediated inhibition of GABA(A) receptors: discrete binding sites underlie subtype specificity | journal = Nature Neuroscience | volume = 6 | issue = 4 | pages = 362–9 | date = April 2003 | pmid = 12640458 | doi = 10.1038/nn1030 | s2cid = 24096465 }}</ref>
* Inverse allosteric agonists: [[beta-carbolines]] (e.g., [[harmine]], [[harmaline]], [[tetrahydroharmine]]).
* Second-order modulators: [[Epigallocatechin gallate|(−)‐epigallocatechin‐3‐gallate]].<ref>{{cite journal | vauthors = Campbell EL, Chebib M, Johnston GA | title = The dietary flavonoids apigenin and (-)-epigallocatechin gallate enhance the positive modulation by diazepam of the activation by GABA of recombinant GABA(A) receptors | journal = Biochemical Pharmacology | volume = 68 | issue = 8 | pages = 1631–8 | date = October 2004 | pmid = 15451406 | doi = 10.1016/j.bcp.2004.07.022 | series = Six Decades of GABA }}</ref>
* Non-competitive channel blockers: [[cicutoxin]], [[oenanthotoxin]], [[pentylenetetrazol]], [[picrotoxin]]{{citation needed|date=April 2019}}, [[thujone]], and [[lindane]].