Editing Inhalational anesthetic (section)

==Endogenous analogous==
[[Endogenous anesthetic|Endogenous analogs]] of inhaled anesthetics are compounds that the body produces and that have the properties and similar mode of action of inhaled anesthetics.<ref>{{cite journal |last1=Lerner |first1=Richard A. |title=A hypothesis about the endogenous analogue of general anesthesia |journal=Proceedings of the National Academy of Sciences |date=9 December 1997 |volume=94 |issue=25 |pages=13375–13377 |doi=10.1073/pnas.94.25.13375 |pmid=9391028 |pmc=33784 |bibcode=1997PNAS...9413375L |doi-access=free }}</ref> Among the gases in the human body, [[carbon dioxide]] is among the most abundant and produces anesthesia from insects to humans.<ref>{{cite journal |last1=Nilson |first1=Theresa L. |last2=Sinclair |first2=Brent J. |last3=Roberts |first3=Stephen P. |title=The effects of carbon dioxide anesthesia and anoxia on rapid cold-hardening and chill coma recovery in Drosophila melanogaster |journal=Journal of Insect Physiology |date=October 2006 |volume=52 |issue=10 |pages=1027–1033 |doi=10.1016/j.jinsphys.2006.07.001|pmid=16996534 |pmc=2048540 }}</ref> {{chem2|CO2}} anesthesia was first demonstrated to the king of France in the early 1800s by [[Henry Hill Hickman]]. Initially {{chem2|CO2}} was thought to work through anoxia, but in the early 1900, increased {{chem2|CO2}} in the lung showed a dramatic increase oxygenation of the brain disproving the anoxia argument.<ref>{{cite journal |last1=Moriarty |first1=John D. |title=Evaluation of Carbon Dioxide Inhalation Therapy |journal=American Journal of Psychiatry |date=April 1954 |volume=110 |issue=10 |pages=765–769 |doi=10.1176/ajp.110.10.765|pmid=13138755 }}</ref> Prior to the development of modern anesthetics, {{chem2|CO2}} was used extensively by psychiatrists in a treatment called carbon dioxide inhalation therapy.<ref>{{cite journal |doi=10.1176/ajp.110.10.765 |title=Evaluation of Carbon Dioxide Inhalation Therapy |date=1954 |last1=Moriarty |first1=John D. |journal=American Journal of Psychiatry |volume=110 |issue=10 |pages=765–769 |pmid=13138755 }}</ref>