Editing Lewis acids and bases (section)

===Applications of Lewis bases===
{{main|Homogeneous catalysis}}
Nearly all electron pair donors that form compounds by binding transition elements can be viewed [[ligand]]s. Thus, a large application of Lewis bases is to modify the activity and selectivity of [[homogeneous catalysis|metal catalysts]]. Chiral Lewis bases, generally [[multidentate]], confer [[chirality (chemistry)|chirality]] on a catalyst, enabling [[asymmetric catalysis]], which is useful for the production of [[pharmaceutical]]s.  The industrial synthesis of the anti-hypertension drug [[mibefradil]] uses a chiral Lewis base (''R''-MeOBIPHEP), for example.<ref name="CompAsymmetricCatalysis">{{cite book
 |title=Comprehensive Asymmetric Catalysis
 |editor1-last=Jacobsen |editor1-first=E.N. 
 |editor2-last=Pfaltz |editor2-first=Andreas 
 |editor3-last=Yamamato |editor3-first=H. 
 |year=1999
 |publisher=Springer
 |location=Berlin; New York
 |isbn=978-3-540-64336-4
 |pages=1443–1445
}}</ref>
[[File:Partial Roche Synthesis of Mibefradil.tif|center|700px]]
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