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Mast cell
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===Allergen process=== Allergen-mediated FcεR1 cross-linking signals are very similar to the signaling event resulting in antigen binding to [[lymphocytes]]. The [[LYN|Lyn]] [[tyrosine kinase]] is associated with the cytoplasmic end of the FcεR1 β chain. The antigen cross-links the FcεR1 molecules, and Lyn tyrosine kinase phosphorylates the ITAMs in the FcεR1 β and γ chain in the cytoplasm. Upon the [[phosphorylation]], the [[Syk]] tyrosine kinase gets recruited to the ITAMs located on the γ chains. This causes activation of the Syk tyrosine kinase, causing it to phosphorylate.<ref name="Role of Mast Cells"/> Syk functions as a signal amplifying kinase activity due to the fact that it targets multiple proteins and causes their activation.<ref name=pmid12217392>{{cite journal |vauthors=Rivera J, Cordero JR, Furumoto Y, etal |title=Macromolecular protein signaling complexes and mast cell responses: a view of the organization of IgE-dependent mast cell signaling |journal=Molecular Immunology |volume=38 |issue=16–18 |pages=1253–8 |date=September 2002 |pmid=12217392 |doi=10.1016/S0161-5890(02)00072-X}}</ref> This [[antigen]] stimulated phosphorylation causes the activation of other proteins in the FcεR1-mediated signaling cascade.<ref>{{cite journal |vauthors=Li W, Deanin GG, Margolis B, Schlessinger J, Oliver JM |title=FcεR1-mediated tyrosine phosphorylation of multiple proteins, including phospholipase Cγ1 and the receptor βγ2 complex, in RBL-2H3 rat basophilic leukemia cells |journal=Molecular and Cellular Biology |volume=12 |issue=7 |pages=3176–82 |date=July 1992 |pmid=1535686 |pmc=364532 |doi=10.1128/MCB.12.7.3176 }}</ref>
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