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Maturation promoting factor
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===Disassembly by anaphase-promoting complex=== MPF is disassembled when [[anaphase-promoting complex]] (APC) polyubiquitinates cyclin B, marking it for degradation in a [[negative feedback]] loop. In intact cells, cyclin degradation begins shortly after the onset of anaphase (late anaphase), the period of mitosis when sister chromatids are separated and pulled toward opposite spindle poles. As the concentration of Cyclin B/CDK1 increases, the heterodimer promotes APC to polyubiquitinate Cyclin B/CDK1.
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