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Midbrain
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==Function== The midbrain is the uppermost part of the [[brainstem]]. Its [[substantia nigra]] is closely associated with [[motor system]] pathways of the [[basal ganglia]]. The human midbrain is [[archipallium|archipallian]] in origin, meaning that its general architecture is shared with the most ancient of [[vertebrate]]s. [[Dopamine]] produced in the substantia nigra and [[ventral tegmental area]] plays a role in movement, movement planning, excitation, motivation and habituation of species from humans to the most elementary animals such as insects. [[Laboratory mice]] from lines that have been [[selectively bred]] for high voluntary [[wheel running]] have enlarged midbrains.<ref>{{cite journal | last1 = Kolb | first1 = E. M. | author-link7 = Theodore Garland, Jr. | last2 = Rezende | first2 = E. L. | last3 = Holness | first3 = L. | last4 = Radtke | first4 = A. | last5 = Lee | first5 = S. K. | last6 = Obenaus | first6 = A. | last7 = Garland | year = 2013 | title = Mice selectively bred for high voluntary wheel running have larger midbrains: support for the mosaic model of brain evolution | journal = [[Journal of Experimental Biology]] | volume = 216 | issue = 3| pages = 515β523 | doi = 10.1242/jeb.076000 | pmid = 23325861 | doi-access = free }}</ref> The midbrain helps to relay information for vision and hearing.
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