Editing Myeloid sarcoma (section)

== Prognostic significance ==
Evidence is conflicting on the [[prognosis|prognostic]] significance of chloromas in patients with acute myeloid leukemia. In general, they are felt to augur a poorer prognosis, with a poorer response to treatment and worse survival;<ref>{{cite journal |vauthors=Byrd JC, Weiss RB, Arthur DC, etal |title=Extramedullary leukemia adversely affects hematologic complete remission rate and overall survival in patients with t(8;21)(q22;q22): results from Cancer and Leukemia Group B 8461 |journal=J. Clin. Oncol. |volume=15 |issue=2 |pages=466–75 |date=February 1997 |pmid=9053467|doi=10.1200/JCO.1997.15.2.466   }} </ref> however, others have reported chloromas associate, as a biologic marker, with other poor prognostic factors, and therefore do not have independent prognostic significance.<ref>{{cite journal  |vauthors=Bisschop MM, Révész T, Bierings M, etal |title=Extramedullary infiltrates at diagnosis have no prognostic significance in children with acute myeloid leukaemia |journal=Leukemia |volume=15 |issue=1 |pages=46–9 |date=January 2001 |pmid=11243398 |doi=10.1038/sj.leu.2401971|doi-access=free }}</ref> In case of primary isolated choloroma, prognosis is better <ref>{{cite journal |vauthors=Imrie KR, Kovacs MJ, Selby D, Lipton J, Patterson BJ, Pantalony D, Poldre P, Ngan BY, Keating A etal |title=Isolated chloroma: the effect of early antileukemic therapy |journal=Annals of Internal Medicine |volume=123 |issue=5 |pages=351–3 |date=September 1995 |pmid=7625623 |doi=10.7326/0003-4819-123-5-199509010-00005 |s2cid=20631629 }}</ref>