Editing Natural killer cell (section)

===Antibody-dependent cell-mediated cytotoxicity (ADCC)===
Infected cells are routinely [[opsonized]] with antibodies for detection by immune cells.  Antibodies that bind to antigens can be recognised by FcγRIII ([[CD16]]) receptors expressed on NK cells, resulting in NK activation, release of cytolytic granules and consequent cell [[apoptosis]]. This is a major killing mechanism of some [[monoclonal antibodies]] like [[Rituximab|rituximab (Rituxan)]], [[ofatumumab | ofatumumab (Azzera)]], and others. The contribution of antibody-dependent cell-mediated cytotoxicity to tumor cell killing can be measured with a specific test that uses [[NK-92]], an immortal line of NK-like cells licensed to [https://nantkwest.com NantKwest, Inc.]: the response of [https://nantkwest.com NK-92 cells] that have been transfected with a high-affinity [[Fc receptor]] are compared to that of the "wild type" NK-92 which does not express the Fc receptor.<ref name=Smyth2002>{{cite journal | vauthors = Smyth MJ, Hayakawa Y, Takeda K, Yagita H | title = New aspects of natural-killer-cell surveillance and therapy of cancer | journal = Nature Reviews. Cancer | volume = 2 | issue = 11 | pages = 850–861 | date = November 2002 | pmid = 12415255 | doi = 10.1038/nrc928 | s2cid = 1430364 }}</ref>