Editing Notch signaling pathway (section)

=== Embryo polarity ===

Notch signaling is required in the regulation of polarity. For example, mutation experiments have shown that loss of Notch signaling causes abnormal anterior-posterior polarity in [[somites]].<ref>{{cite journal | vauthors = Feller J, Schneider A, Schuster-Gossler K, Gossler A | title = Noncyclic Notch activity in the presomitic mesoderm demonstrates uncoupling of somite compartmentalization and boundary formation | journal = Genes & Development | volume = 22 | issue = 16 | pages = 2166–2171 | date = August 2008 | pmid = 18708576 | pmc = 2518812 | doi = 10.1101/gad.480408 }}</ref> Also, Notch signaling is required during left-right asymmetry determination in vertebrates.<ref>{{cite journal | vauthors = Levin M | title = Left-right asymmetry in embryonic development: a comprehensive review | journal = Mechanisms of Development | volume = 122 | issue = 1 | pages = 3–25 | date = January 2005 | pmid = 15582774 | doi = 10.1016/j.mod.2004.08.006 | s2cid = 15211728 | doi-access =  }}</ref>

Early studies in the [[nematode]] model organism [[Caenorhabditis elegans|''C. elegans'']] indicate that Notch signaling has a major role in the induction of mesoderm and cell fate determination.<ref name=pmid3677168/> As mentioned previously, C. elegans has two genes that encode for partially functionally redundant Notch homologs, ''glp-1'' and ''lin-12''.<ref>{{cite journal | vauthors = Lambie EJ, Kimble J | title = Two homologous regulatory genes, lin-12 and glp-1, have overlapping functions | journal = Development | volume = 112 | issue = 1 | pages = 231–240 | date = May 1991 | pmid = 1769331 | doi = 10.1242/dev.112.1.231 }}</ref> During C. elegans, GLP-1, the C. elegans Notch homolog, interacts with APX-1, the C. elegans Delta homolog. This signaling between particular blastomeres induces differentiation of cell fates and establishes the dorsal-ventral axis.<ref>{{cite book | title=Developmental biology| edition=11th| author=Gilbert SF| year=2016| pages=272| publisher=Sinauer| isbn=978-1-60535-470-5}}{{page needed|date=February 2020}}</ref>