Editing Point mutation (section)

===Cancer===
Point mutations in multiple tumor suppressor proteins cause [[cancer]]. For instance, point mutations in Adenomatous Polyposis Coli promote tumorigenesis.<ref name="APC point mutations">{{cite journal |vauthors=Minde DP, Anvarian Z, Rüdiger SG, Maurice MM |title=Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer? |journal=Mol. Cancer |volume=10 |pages=101 |year=2011 |pmid=21859464 |pmc=3170638 |doi=10.1186/1476-4598-10-101 |doi-access=free }}</ref> A novel assay, [[Fast parallel proteolysis (FASTpp)]], might help swift screening of specific stability defects in individual cancer patients.<ref>{{cite journal |vauthors=Minde DP, Maurice MM, Rüdiger SG |title=Determining biophysical protein stability in lysates by a fast proteolysis assay, FASTpp |journal=PLOS ONE |volume=7 |issue=10 |pages=e46147 |year=2012 |pmid=23056252 |pmc=3463568 |doi=10.1371/journal.pone.0046147 |bibcode=2012PLoSO...746147M |doi-access=free }}</ref>