Editing Precocious puberty (section)

=== Side effects ===
The most common side effects reported include nonspecific headaches, hot flashes, and implant-related skin reactions.<ref>{{cite journal | vauthors = Lewis KA, Eugster EA | title = Experience with the once-yearly histrelin (GnRHa) subcutaneous implant in the treatment of central precocious puberty | language = English | journal = Drug Design, Development and Therapy | volume = 3 | pages = 1–5 | date = September 2009 | pmid = 19920916 | doi = 10.2147/DDDT.S3298 | doi-access = free | pmc = 2769233 }}</ref>

A systematic review of studies investigating the long-term effects of treating precocious puberty with GnRH agonists found that [[Bone density|bone mineral density]] decreases during treatment but normalizes afterward, with no lasting effects on [[peak bone mass]].<ref name="Soliman">{{cite journal |last1=Soliman |first1=Ashraf T. |last2=Alaaraj |first2=Nada |last3=De Sanctis |first3=Vincenzo |last4=Hamed |first4=Noor |last5=Alyafei |first5=Fawzia |last6=Ahmed |first6=Shayma |title=Long-term health consequences of central precocious/early puberty (CPP) and treatment with Gn-RH analogue: a short update: Long term consequences of precocious puberty |journal=Acta Biomedica: Atenei Parmensis |date=5 December 2023 |volume=94 |issue=6 |pages=e2023222 |doi=10.23750/abm.v94i6.15316 |pmid=38054666|pmc=10734238 }}</ref>