Editing Progestogen (medication) (section)

===Gynecological disorders===

====Menstrual disorders====
Progestogens are used to treat [[menstrual disorder]]s such as [[secondary amenorrhea]] and [[dysfunctional uterine bleeding]].<ref name="ClarkHarvey2011" /><ref name="Bhattacharya2003" /> In a normal [[menstrual cycle]], declining levels of progesterone trigger [[menstruation]]. Progestogens such as [[norethisterone acetate]] and [[medroxyprogesterone acetate]] may be used to artificially induce progesterone-associated [[breakthrough bleeding]].<ref name="pmid11041215">{{cite journal |vauthors=Hickey M, Fraser IS | title = A functional model for progestogen-induced breakthrough bleeding | journal = Hum. Reprod. | volume = 15 | issue = Suppl 3 | pages = 1–6 |date=August 2000 | pmid = 11041215 | doi = 10.1093/humrep/15.suppl_3.1| doi-access = free}}</ref>

The [[progestogen challenge test]] or progestogen withdrawal test is used to diagnose [[amenorrhea]]. Due to the availability of assays to measure estrogen levels, it is now rarely used.

====Uterine disorders====
Progestogens are used in the prevention and treatment of [[uterine disorder]]s such as [[endometrial hyperplasia]], [[endometriosis]], [[uterine fibroids]], and [[uterine hypoplasia]].

====Breast disorders====
Progestogens are used to treat [[benign tumor|benign]] [[breast disorder]]s.<ref name="pmid20383772">{{cite journal | vauthors = Schindler AE | title = Dydrogesterone and other progestins in benign breast disease: an overview | journal = Archives of Gynecology and Obstetrics | volume = 283 | issue = 2 | pages = 369–371 | date = February 2011 | pmid = 20383772 | doi = 10.1007/s00404-010-1456-7 | s2cid = 9125889 }}</ref><ref name="pmid12227885">{{cite journal | vauthors = Winkler UH, Schindler AE, Brinkmann US, Ebert C, Oberhoff C | title = Cyclic progestin therapy for the management of mastopathy and mastodynia | journal = Gynecological Endocrinology | volume = 15 | issue = Suppl 6 | pages = 37–43 | date = December 2001 | pmid = 12227885 | doi = 10.1080/gye.15.s6.37.43 | s2cid = 27589741 }}</ref> They are associated not only with a reduction in [[breast pain]], but also a decrease in [[breast]] [[cell proliferation]], a decrease in [[mammary gland|breast gland]] size, and a disappearance of breast [[nodule (medicine)|nodularity]].<ref name="pmid20383772" /><ref name="pmid12227885" /><ref name="pmid25113944" /> Progestogens that have been used for such purposes include [[topical progesterone]], [[dydrogesterone]], [[promegestone]], [[lynestrenol]], [[medroxyprogesterone acetate]], [[dienogest]], and [[medrogestone]].<ref name="pmid20383772" /><ref name="pmid12227885" /><ref name="BińkowskaWoroń2015">{{cite journal | vauthors = Bińkowska M, Woroń J | title = Progestogens in menopausal hormone therapy | journal = Przeglad Menopauzalny = Menopause Review | volume = 14 | issue = 2 | pages = 134–143 | date = June 2015 | pmid = 26327902 | pmc = 4498031 | doi = 10.5114/pm.2015.52154 }}</ref><ref name="pmid25113944">{{cite journal | vauthors = Ruan X, Mueck AO | title = Systemic progesterone therapy--oral, vaginal, injections and even transdermal? | journal = Maturitas | volume = 79 | issue = 3 | pages = 248–255 | date = November 2014 | pmid = 25113944 | doi = 10.1016/j.maturitas.2014.07.009 }}</ref>

Progestogens are used in the treatment of [[breast hypoplasia]] and [[lactation insufficiency]]. This is because they induce [[lobuloalveolar]] [[breast development|development]] of the [[breast]]s, which is required for [[lactation]] and [[breastfeeding]].