Editing Serotonin transporter (section)

=== I425V ===
I425V is a rare mutation on the ninth exon.
In 2003, researchers from Japan and the US reported that they had found this genetic variation in unrelated families with [[OCD]], and have found that it leads to faulty transporter function and regulation. A second variant in the same gene of some patients with this mutation suggests a genetic "double hit", resulting in greater biochemical effects and more severe symptoms.<ref>{{cite journal | vauthors = Ozaki N, Goldman D, Kaye WH, Plotnicov K, Greenberg BD, Lappalainen J, Rudnick G, Murphy DL | title = Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype | journal = Molecular Psychiatry | volume = 8 | issue = 11 | pages = 933–936 | date = November 2003 | pmid = 14593431 | doi = 10.1038/sj.mp.4001365 | s2cid = 2171955 | doi-access =  }}
News article:
* {{Cite news
 |agency       = Reuters
 |title        = Gene Found for Obsessive-Compulsive Disorder
 |publisher    = Mental Health E-News
 |date         = 27 October 2003
 |url          = http://www.nyaprs.org/Pages/View_ENews.cfm?ENewsID=2842
 |access-date   = 25 January 2008
 |archive-url  = https://web.archive.org/web/20061006182857/http://www.nyaprs.org/Pages/View_ENews.cfm?ENewsID=2842
 |archive-date = 6 October 2006
 |url-status     = dead
 |df           = dmy-all
}}</ref><ref>
{{cite journal | vauthors = Delorme R, Betancur C, Wagner M, Krebs MO, Gorwood P, Pearl P, Nygren G, Durand CM, Buhtz F, Pickering P, Melke J, Ruhrmann S, Anckarsäter H, Chabane N, Kipman A, Reck C, Millet B, Roy I, Mouren-Simeoni MC, Maier W, Råstam M, Gillberg C, Leboyer M, Bourgeron T | title = Support for the association between the rare functional variant I425V of the serotonin transporter gene and susceptibility to obsessive compulsive disorder | journal = Molecular Psychiatry | volume = 10 | issue = 12 | pages = 1059–1061 | date = December 2005 | pmid = 16088327 | pmc = 2547479 | doi = 10.1038/sj.mp.4001728 }}</ref><ref>{{Cite web
 | author = Stephen Wheless
 | title = "The OCD Gene" Popular Press v. Scientific Literature: Is SERT Responsible for Obsessive-Compulsive Disorder?
 | publisher = [[Davidson College]]
 | url = http://www.bio.davidson.edu/courses/genomics/2004/Wheless/SERT.html
 | access-date = 12 June 2008
}}</ref>