Editing Strangers with Candy (section)

===Main characters===
* [[Stephen Colbert]] as Charles "Chuck" Noblet, the school's history teacher and sponsor of the school newspaper, ''The Donkey Trouser''. He and his wife Claire have a son, Seamus, and he is in a secret sexual relationship with Geoffrey Jellineck.
* [[Paul Dinello]] as Geoffrey Jellineck, the school's art teacher. He is an emotionally fragile and narcissistic man who is engaged in a secret homosexual relationship with Chuck Noblet.
* [[Greg Hollimon]] as Principal Onyx Blackman, Principal of Flatpoint High School.  His image is prominently displayed around the school, in classrooms, lockers, and even paper towels.
* [[Roberto Gari]] as Guy Blank (season 1; guest season 2), Jerri's biological father, shown only in a motionless state during mid-action. In the [[Strangers with Candy (film)|film]], he is replaced by [[Dan Hedaya]].
* [[Deborah Rush]] as Sara Blank (season 1; recurring seasons 2–3), Jerri's hateful stepmother.
* [[Larc Spies]] as Derrick Blank (season 1; recurring seasons 2–3), Jerri's arrogant teenage half-brother. He plays quarterback for the Flatpoint Donkeys football team. In the [[Strangers with Candy (film)|film]], he is replaced by [[Joseph Cross (actor)|Joseph Cross]].
* [[Amy Sedaris]] as Geraldine "Jerri" Antonia Blank, a 46-year-old ex-con, ex-junkie, ex-prostitute, and high-school freshman at Flatpoint High.