Editing Synaptic vesicle (section)

===="Kiss-and-run"====
The second mechanism by which synaptic vesicles are recycled is known as [[kiss-and-run fusion]]. In this case, the synaptic vesicle "kisses" the cellular membrane, opening a small pore for its neurotransmitter payload to be released through, then closes the pore and is recycled back into the cell.<ref name=3synapse/> The kiss-and-run mechanism has been a hotly debated topic. Its effects have been observed and recorded; however the reason behind its use as opposed to full collapse fusion is still being explored. It has been speculated that kiss-and-run is often employed to conserve scarce vesicular resources as well as being utilized to respond to high-frequency inputs.<ref name=4synapse>{{Cite journal | last1 = Harata | first1 = N. C. | last2 = Aravanis | first2 = A. M. | last3 = Tsien | first3 = R. W. | doi = 10.1111/j.1471-4159.2006.03987.x | title = Kiss-and-run and full-collapse fusion as modes of exo-endocytosis in neurosecretion | journal = Journal of Neurochemistry | volume = 97 | issue = 6 | pages = 1546–1570 | year = 2006 | pmid = 16805768 | s2cid = 36749378 }}</ref> Experiments have shown that kiss-and-run events do occur. First observed by [[Bernard Katz|Katz]] and del Castillo, it was later observed that the kiss-and-run mechanism was different from full collapse fusion in that cellular [[capacitance]] did not increase in kiss-and-run events.<ref name=4synapse/> This reinforces the idea of a kiss-and-run fashion, the synaptic vesicle releases its payload and then separates from the membrane.