Editing Transcription factor (section)

==== Response to environment ====

Not only do transcription factors act downstream of signaling cascades related to biological stimuli but they can also be downstream of signaling cascades involved in environmental stimuli.  Examples include [[heat shock factor]] (HSF), which upregulates genes necessary for survival at higher temperatures,<ref name="pmid18239856">{{Cite journal |vauthors=Shamovsky I, Nudler E |date=March 2008 |title=New insights into the mechanism of heat shock response activation |journal=Cellular and Molecular Life Sciences |volume=65 |issue=6 |pages=855–61 |doi=10.1007/s00018-008-7458-y |pmc=11131843 |pmid=18239856 |s2cid=9912334}}</ref> [[hypoxia inducible factor]] (HIF), which upregulates genes necessary for cell survival in low-oxygen environments,<ref name="pmid18202826">{{Cite journal |vauthors=Benizri E, Ginouvès A, Berra E |date=April 2008 |title=The magic of the hypoxia-signaling cascade |journal=Cellular and Molecular Life Sciences |volume=65 |issue=7–8 |pages=1133–49 |doi=10.1007/s00018-008-7472-0 |pmc=11131810 |pmid=18202826 |s2cid=44049779}}</ref> and [[sterol regulatory element binding protein]] (SREBP), which helps maintain proper [[lipid]] levels in the cell.<ref name="pmid15457548">{{Cite journal |vauthors=Weber LW, Boll M, Stampfl A |date=November 2004 |title=Maintaining cholesterol homeostasis: sterol regulatory element-binding proteins |journal=World Journal of Gastroenterology |volume=10 |issue=21 |pages=3081–7 |doi=10.3748/wjg.v10.i21.3081 |pmc=4611246 |pmid=15457548 |doi-access=free}}</ref>