Editing Transdermal patch (section)

=== Matrix ===
The matrix system has a drug layer of a semisolid matrix containing a drug solution or suspension. The adhesive layer in this patch surrounds the drug layer, partially overlaying it. The release rate is determined by the physical properties of the matrix.<ref name=":0" /> Also known as a monolithic device. Limited research indicates that it may be possible to cut some matrix patches to provide lower doses, provided the cut part not immediately used is stored at cool temperatures.<ref>{{Cite journal |last1=Ankarberg-Lindgren |first1=Carina |last2=Gawlik |first2=Aneta |last3=Kriström |first3=Berit |last4=Mazzanti |first4=Laura |last5=Ruijgrok |first5=Elisabeth J. |last6=Sas |first6=Theo C. J. |date=April 2019 |title=Estradiol matrix patches for pubertal induction: stability of cut pieces at different temperatures |journal=Endocrine Connections |volume=8 |issue=4 |pages=360–366 |doi=10.1530/EC-19-0025 |issn=2049-3614 |pmc=6454296 |pmid=30851161}}</ref>