Editing Two and a Half Men (section)

=== Guest stars ===
Guest stars have included:
* [[Aisha Tyler]] as an adoption lawyer to whom Walden goes when he wants a child (season 12, episode 1)
* [[Alana de la Garza]] as Crystal, Laura Lang's assistant (season 1, episode 21)
* [[Alicia Witt]] as Dolores Pasternak, Jake's teacher who becomes a stripper (season 6)
* [[Allison Janney]] as Beverly, Alan's [[online dating]] partner (season 4)
* [[Amy Hill]] as Mrs. Wiggins, Alan's receptionist after Melissa leaves him (season 7)
* [[Annie Potts]] as Lenore, mother of Judith and Liz (season 7)
* [[Arnold Schwarzenegger]] as Lieutenant Wagner ("Of Course He's Dead", series finale)
* [[Brad Paisley]] as Derek (season 11, episode 22), Gretchen Martin's fiancé, before she broke it off to date Alan
* Brenda Koo as Julie (season 12, episode 7)
* [[Brit Morgan]] as a girl Walden picks up at a bar (season 10, episode 1)
* [[Brooke Shields]] as Danielle, Charlie and Alan's neighbor (season 4)
* [[Camryn Manheim]] as Daisy, Berta's sister (season 2)
* [[Carol Kane]] as Shelly, Melissa's mother (season 6)
* [[Chris O'Donnell]] as Jill/Bill Shrader, Charlie's [[transgender]] ex-girlfriend (season 1, episode 18)
* [[Christian Slater]] as himself (series finale)
* [[Christina Moore]] as Cynthia Sullivan, Judith's best friend (season 5)
* [[Chuck Lorre]] as himself, the program's producer ("[[#ep261/262|Of Course He's Dead]]", series finale)
* [[Cloris Leachman]] as Norma, Charlie and Alan's neighbor, Alan's "sugar momma" and Charlie's former "sugar momma" (season 3)
* [[David Denman]] as Jack (season 12), an old friend of Walden whom he meets at the bar
* [[Deanna Russo]] as Laurel (season 12, episode 7)
* [[Denise Richards]] as Lisa, Charlie's former girlfriend (season 1, episode 10; season 2, episode 9)
* [[Diedrich Bader]] as Dirk, a Denver pawn-shop owner (season 11, episode 21)
* [[Diora Baird]] as Wanda, a girl who chases after Charlie when he is engaged to Chelsea (season 6, episode 16)
* [[Eddie Van Halen]] as himself (season 7, episode 1)
* [[Elvis Costello]] as himself, Charlie's support, whisky and cigar group buddy (season 2, episode 1)
* [[Emilio Estevez]] as Andy, Charlie's long-time friend who dies before him (season 6, episode 11)
* [[Emily Osment]] as Ashley, Jake's girlfriend (season 10, episode 20)
* [[Emily Rose (actress)|Emily Rose]] as Janine (season 6, episode 12)
* [[Enrique Iglesias]] as Fernando, Charlie's carpenter/handyman (season 4, episode 23)
* [[Eric Allan Kramer]] as Bill (season 1)
* [[Erinn Hayes]] as Gretchen, a one-night stand of Alan's (season 8, episode 5)
* Fire Ice as Rapper Cool Dawgie
* [[Frances Fisher]] as Priscilla Honeycutt, Alan's patient (season 7, episode 19)
* [[Gail O'Grady]] as Mandi, mother of Kandi, ex-wife of Andy and brief love interest of Charlie (season 3)
* [[Garry Marshall]] as Garry, one of Marty's friends (season 11, episode 13)
* [[Gary Busey]] as himself, Alan's roommate in a sanitarium (season 9)
* [[Georgia Engel]] as Jean, Lyndsey's mother (season 9, episodes 19–20)
* [[Harry Dean Stanton]] as himself, Charlie's support, whisky and cigar group buddy (season 2, episode 1)
* [[Heather Locklear]] as Laura Lang, Alan's divorce attorney (season 1, episode 21)
* [[Hilary Duff]] as Stacy, a ditzy one-night stand of Walden's (season 10, episode 23)
* [[Ion Overman]] as Vicki, Charlie Waffles' supermarket pickup (season 5, episode 8)
* [[Iqbal Theba]] as Don, a taxi driver who Charlie insults (season 6, episode 13) 
* [[Jack Plotnick]] as Mike (season 5, episode 18)
* [[Jaime Pressly]] as Tammy, Jake's cougar girlfriend (season 10)
* [[James Earl Jones]] as himself (season 6, episode 11)
* [[Jason Alexander]] as Dr. Goodman, Alan's doctor (season 9, episode 23)
* [[Jeff Probst]] as himself, Walden and Alan's love rival (season 11)
* [[Jenna Elfman]] as Frankie (season one, episodes 15 and 16) and as Dharma (season 9, episode 1)
* [[Jeri Ryan]] as Sherri, Charlie's and later Alan's girlfriend (season 2, episodes 5 and 19; season 9, episode 1)
* [[Jessica Collins (actress born 1971)|Jessica Collins]] as Gloria, one of Charlie's one-night stands (season 4, episode 11)
* [[Jodi Lyn O'Keefe]] as Isabella (season 3, episode 6)
* [[John Amos]] as Ed, boyfriend of Chelsea's father Tom (season 7)
* [[John Stamos]] as himself (seasons 9 and 12)
* [[Jon Lovitz]] as Archie Baldwin, Charlie's nemesis to win the advertising jingle award (season 3, episode 17)
* [[Josie Davis]] as Sandy, a girlfriend of Alan's (season 3)
* [[Judd Nelson]] as Chris McElroy, ex-husband of Alan's love interest, Lyndsey, and Eldridge's father (season 8)
* [[Julia Campbell]] as Francine, Jake's teacher (season 3)
* [[Kate Lang Johnson|Kate Miner]] as Nadine Hore (season 11, episode 9)
* [[Katherine LaNasa]] as Lydia, Charlie's oedipal girlfriend and Evelyn's doppelgänger (season 4, episodes 6 and 10)
* [[Kathy Bates]] as "Charlie" in the afterlife (season 9, episode 22)
* [[Katy Mixon]] as Betsy, a married woman whom Charlie purports to marry after his breakup with Chelsea (season 7, episodes 7 and 16)
* [[Ken Jeong]] as a male nurse (season 2, episode 17)
* [[Ken Lerner]] as Dr. Levine (season 6, episode 24)
* [[Kevin Sorbo]] as Andy, father of Kandi, ex-husband of Mandi and brief love interest of Judith (season 3)
* Kris Iyer as Dr. Prajneep (season 1, episode 17; season 4, episode 16; season 5, episode 1)<ref>{{cite web|url=https://www.imdb.com/character/ch0067249/|title=Dr. Prajneep|publisher=IMDb.com|access-date=July 22, 2012|archive-date=July 2, 2013|archive-url=https://web.archive.org/web/20130702021206/http://www.imdb.com/character/ch0067249/|url-status=live}}</ref>
* [[Liz Vassey]] as Michelle (seasons 8–9)
* [[Lucy Lawless]] as Pamela, the ex-wife of the gay ad executive (season 2, episode 18)
* [[Lynda Carter]] as herself (season 11)
* [[Marco Sanchez]] as Hector (season 4, episode 12)
* [[Marilu Henner]] as Linda, Walden's older, more mature love interest (season 10, episode 23)
* [[Martin Sheen]] as Harvey, Rose's father and Evelyn's fling (season 3)
* [[Matthew Marsden]] as Nigel (season 9, episodes 15 and 17), Zoey's ex-husband
* [[Meagen Fay]] as Martha Melini, Chelsea's mother (seasons 6–7)
* [[Megan Fox]] as Prudence, Berta's granddaughter (season 1, episode 12)
* [[Michael Bolton]] as himself (seasons 10 and 12)
* [[Michael Clarke Duncan]] as Jerome Burnette, a retired football player, Charlie and Alan's neighbor and the father of Celeste Burnette (season 6)
* [[Mike Conners]] as Hugo, a brief love interest of Evelyn (season 4, episode 24)
* [[Mila Kunis]] as Vivian, a free-spirit hiker and Walden's love interest (season 11, episode 19)
* [[Morgan Fairchild]] as Donna (Charlie's ego) (season 4, episode 16)
* [[Nadia Bjorlin]] as Jill, a young woman who sleeps with Russell, and Evelyn's one-time lover (season 8)
* [[Noel Fisher]] as Freddie, Prudence's fiancé (season 1, episode 12)
* [[Orson Bean]] as Norman, an old man whose trophy wife had sex with Charlie (season 2, episode 24)
* [[Paget Brewster]] as Jamie Eckleberry, Charlie and Alan's high-school classmate (season 2, episode 12)
* [[Rena Sofer]] as Chrissy, the "mother" of Charlie's "son" (season 6, episode 1)
* [[Richard Kind]] as Artie, Charlie's manager (season 5, episode 8)
* [[Richard Lewis (comedian)|Richard Lewis]] as Stan, Charlie's accountant (season 1, episode 14)
* [[Sam Lerner]] as Andrew, one of Jake's classmates (season 1, episode 8)
* [[Sara Erikson]] as Jennifer, Jake's one-time, older girlfriend (season 9, episode 17)
* [[Sara Rue]] as Naomi, Berta's daughter (season 4)
* [[Scott Bakula]] as Jerry, Ashley's ex-boyfriend (season 10, episode 20)
* [[Sean Penn]] as himself, Charlie's support, whisky and cigar group buddy (season 2, episode 1)
* Skyler Caleb as Serge (season 7, episode 5)
* [[Stacy Keach]] as Tom Melini, Chelsea's father (season 7)
* [[Stephanie Jacobsen]] as Penelope, Charlie's former lover (season 9, episode 2)
* [[Steve Lawrence]] as Steve, one of Marty's friends (season 11, episode 13)
* [[Steven Eckholdt]] as Brad, Alan's lawyer (season 7)
* [[Steven Tyler]] as himself, Charlie and Alan's neighbor and Berta's one-time employer (season 1, episode 4; season 4, episode 2)
* [[Susan Blakely]] as Angie, an author Charlie met at a bookstore (season 5, episodes 18 and 19)
* [[Taylor Cole]] as Melanie Laughlin (season 9)
* [[Teri Hatcher]] as Liz, Judith's sister (season 1, episode 19)
* [[Thomas Gibson]] as Greg (season 9, episode 1)
* [[Tim Conway]] as Tim, one of Marty's friends (season 11, episode 13)
* [[Tinashe|Tinashe Kachingwe]] as Celeste Burnette, Jake's ex-girlfriend (seasons 6–7)
* [[Tony Tripoli]] as Phillip, Evelyn's hairdresser (season 4)
* [[Travis Van Winkle]] as Dylan (season 9, episode 14), a young and rich man who briefly dates Lyndsey
* [[Tricia Helfer]] as Gail, Chelsea's friend (seasons 7 and 9)
* [[Wayne Wilderson]] as Roger, Evelyn's co-worker (season 4)
* [[Will Sasso]] as Andrew, a friend of Charlie's who works in a recording studio (season 7, episode 1)
* [[Willie Garson]] as Dr. Steven Staven, Lyndsey's gynecologist (season 10, episode 14)
* [[Yvette Nicole Brown]] as Mandy (season 1, episode 23)
* [[ZZ Top]] as themselves (season 7, episode 21)

As part of a [[#CSI: Crime Scene Investigation|crossover]] from the writers and executive producer of ''[[CSI: Crime Scene Investigation]]'', [[George Eads]] made a brief [[cameo appearance]] on the [[Fish in a Drawer|May 5, 2008, episode]].<ref>{{cite magazine|last=Rice|first=Lynette|title=George Eads to cameo on 'Two and a Half Men'|url=http://hollywoodinsider.ew.com/2008/04/george-eads-cam.html|magazine=Entertainment Weekly|date=April 12, 2008|access-date=April 24, 2008|archive-url=https://web.archive.org/web/20080426031404/http://hollywoodinsider.ew.com/2008/04/george-eads-cam.html|archive-date=April 26, 2008|url-status=dead}}</ref>

Charlie Sheen's real-life brother [[Emilio Estevez]] has guest-starred as an old friend of Charlie's;<ref>{{cite web|url=https://www.tvguide.com/News/Estevez-Sheen-Men-35396.aspx|title=Two Brothers to Team on ''Two and a Half Men''|work=Tvguide.com|date=November 6, 2008|access-date=August 21, 2011|archive-date=October 29, 2020|archive-url=https://web.archive.org/web/20201029030510/https://www.tvguide.com/news/estevez-sheen-men-35396/|url-status=live}}</ref> his father [[Martin Sheen]] has appeared as Rose's father. Sam Sheen, the real-life daughter of [[Denise Richards]] and Charlie Sheen, appeared as Lisa's daughter on November 22, 2004.<ref>{{IMDb name|id=1775196|name=Sam Sheen}}</ref> [[Mila Kunis]], Ashton Kutcher's fiancée and later wife, appeared on the show as his love interest in season 11.