Editing C-terminus (section)

===C-terminal domain===
[[File: ARN pol II en accion.jpg| thumb|300 px|RNA POL II in action.]]

The C-terminal domain of some proteins has specialized functions. In humans, the CTD of [[RNA polymerase II]] typically consists of up to 52 [[Repeated sequence (DNA)|repeats]] of the sequence [[Tyrosine|Tyr]]-Ser-[[Proline|Pro]]-[[Threonine|Thr]]-Ser-Pro-Ser.<ref>{{cite journal |author=Meinhart A, Cramer P |title=Recognition of RNA polymerase II carboxy-terminal domain by 3'-RNA-processing factors |journal=Nature |volume=430 |issue=6996 |pages=223–6 |date=July 2004 |pmid=15241417 |doi=10.1038/nature02679 |bibcode=2004Natur.430..223M |s2cid=4418258 |hdl=11858/00-001M-0000-0015-8512-8 |url=https://resolver.sub.uni-goettingen.de/purl?gro-2/1538 |hdl-access=free }}</ref> This allows other proteins to bind to the C-terminal domain of RNA polymerase in order to activate polymerase activity. These domains are then involved in the [[DNA transcription#Initiation|initiation]] of DNA transcription, the [[capping enzyme|capping]] of the [[Messenger RNA|RNA transcript]], and attachment to the [[spliceosome]] for [[RNA splicing]].<ref>{{cite journal |author=Brickey WJ, Greenleaf AL |title=Functional studies of the carboxy-terminal repeat domain of Drosophila RNA polymerase II in vivo |journal=Genetics |volume=140 |issue=2 |pages=599–613 |date=June 1995 |doi=10.1093/genetics/140.2.599 |pmid=7498740 |pmc=1206638 }}</ref>