Editing Cytogenetics (section)

===Beginnings of molecular cytogenetics===
In the 1980s, advances were made in [[molecular cytogenetics]]. While radioisotope-labeled probes had been hybridized with [[DNA]] since 1969, movement was now made in using fluorescent-labeled probes. Hybridizing them to chromosomal preparations using existing techniques came to be known as [[fluorescence in situ hybridization|fluorescence ''in situ'' hybridization]] (FISH).<ref>{{cite book |last1=Gupta |first1=P. K. |title=Cytogenetics |date=2007 |publisher=Rastogi Publications |isbn=978-81-7133-737-8 }}{{page needed|date=October 2020}}</ref> This change significantly increased the usage of probing techniques as fluorescent-labeled probes are safer. Further advances in micromanipulation and examination of chromosomes led to the technique of [[chromosome microdissection]] whereby aberrations in chromosomal structure could be isolated, cloned, and studied in ever greater detail.{{cn|date=February 2024}}