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Datura wrightii
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===Recreational=== ''Datura wrightii'' has also been used to induce hallucination for recreational purposes. Internal use of the plant material can induce auditory and visual hallucinations similar to those of ''[[Datura stramonium]]'', with the active compounds being concentrated in the [[capsule (fruit)|seed capsules]] and [[root]]s; concentrations vary widely between samples, and onset is slow. This makes dosage estimation difficult and adds further risk to the administration of material that already has potentially lethal side effects. [[Scopolamine]] is the primary active molecule; it is related to [[atropine]], with a similar, largely [[anticholinergic]] activity. Effects may include dry mouth, [[hyperthermia]], profuse sweating, decreased sweating, impairment, drowsiness, restlessness, lethargy, illusions, changes in [[visual perception]], [[delirium]], [[psychosis]] and [[anterograde amnesia]] - along with the afore-mentioned hallucinations and sensory distortions. These compounds also induce a profound [[mydriasis]] and suppress eye [[saccades]], resulting in considerable degradation of [[visual acuity]], often to the point of [[Visual impairment|functional blindness]]. This may persist, to a reduced degree, for days. The combined effect may result in a panic state in the user, a particularly dangerous situation in someone temporarily deprived of useful vision; users are prone to serious accidental injury. Scopolamine induces respiratory depression at hallucinogenic doses. The combination of anesthesia (in the hospital) and ''Datura'' is usually fatal due to combined respiratory depression.<ref name=Garcia/> [[Seizure]]s as well as fevers as high as {{convert|43|Β°C|Β°F|abbr=on}} have been reported.
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