Editing GABAA receptor (section)

=== Effects ===
Ligands which contribute to receptor activation typically have [[anxiolytic]], [[anticonvulsant]], [[amnesic]], [[sedative]], [[hypnotic]], [[euphoriant]], and [[muscle relaxant]] properties. Some such as [[muscimol]] and the [[z-drugs]] may also be [[hallucinogenic]].{{Citation needed|date=October 2015}} Ligands which decrease receptor activation usually have opposite effects, including [[Anxiogenic|anxiogenesis]] and [[convulsion]].{{Citation needed|date=October 2015}} Some of the subtype-selective negative allosteric modulators such as [[α5IA|α<sub>5</sub>IA]] are being investigated for their [[nootropic]] effects, as well as treatments for the unwanted side effects of other GABAergic drugs.<ref name="pmid16326923">{{cite journal | vauthors = Dawson GR, Maubach KA, Collinson N, Cobain M, Everitt BJ, MacLeod AM, Choudhury HI, McDonald LM, Pillai G, Rycroft W, Smith AJ, Sternfeld F, Tattersall FD, Wafford KA, Reynolds DS, Seabrook GR, Atack JR | title = An inverse agonist selective for alpha5 subunit-containing GABAA receptors enhances cognition | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 316 | issue = 3 | pages = 1335–45 | date = March 2006 | pmid = 16326923 | doi = 10.1124/jpet.105.092320 | s2cid = 6410599 | url = http://pdfs.semanticscholar.org/22aa/5af270a5dff6b125aadd1c231dd0bd464782.pdf | archive-url = https://web.archive.org/web/20190220023037/http://pdfs.semanticscholar.org/22aa/5af270a5dff6b125aadd1c231dd0bd464782.pdf | url-status = dead | archive-date = 2019-02-20 }}</ref> Advances in molecular pharmacology and genetic manipulation of rat genes have revealed that distinct subtypes of the GABA<sub>A</sub> receptor mediate certain parts of the anaesthetic behavioral repertoire.<ref>{{cite journal |vauthors=Weir CJ, Mitchell SJ, Lambert JJ |title=Role of GABAA receptor subtypes in the behavioural effects of intravenous general anaesthetics |journal=Br J Anaesth |volume=119 |issue=suppl_1 |pages=i167–i175 |date=December 2017 |pmid=29161398 |doi=10.1093/bja/aex369 }}</ref>