Editing HIV vaccine development (section)

==Classification of possible vaccines==
Theoretically, any possible HIV vaccine must inhibit or stop the HIV virion replication cycle.<ref>{{cite book | last1 = Collier | first1 = Leslie | last2 = Balows | first2 = Albert | last3 = Sussman | first3 = Max | date = 1998 | series = Topley and Wilson's Microbiology and Microbial Infections | edition = ninth | volume = 1 | title = Virology | editor1-last = Mahy | editor1-first = Brian | editor2-last = Collier | editor2-first =  Leslie | name-list-style = vanc | publisher = Hodder Education Publishers | isbn = 978-0-340-66316-5 | pages = 75–91 }}</ref> The targets of a vaccine could be the following stages of the HIV virion cycle:
* Stage I. Free state
* Stage II. Attachment
* Stage III. Penetration
* Stage IV. Uncoating
* Stage V. Replication
* Stage VI. Assembling
* Stage VII. Releasing

Therefore, the following list comprises the current possible approaches for an HIV vaccine:

===Filtering virions from blood (Stage I)===
* Biological, chemical and/or physical approaches for removing the HIV virions from the blood.

===Approaches to catching the virion (Stage I-III, VI, VII)===
* [[Phagocytosis]] of the HIV virions.
* Chemical or organically based capture (creation of any skin or additional membrane around the virion) of HIV virions
* Chemical or organic attachments to the virion

===Approaches to destroying or damaging the virion or its parts (Stage I-VII)===
Here, "damage" means inhibiting or stopping the ability of virion to process any of the ''Phase II-VII''. Here are the different classification of methods:
* By nature of method:
** Physical methods (''Stage I-VII'')
** Chemical and biological methods (''Stage I-VII'')
* By damaging target of the [[HIV#Structure and genome|HIV virion structure]]:<ref>{{cite journal | vauthors = McGovern SL, Caselli E, Grigorieff N, Shoichet BK | title = A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening | journal = Journal of Medicinal Chemistry | volume = 45 | issue = 8 | pages = 1712–22 | date = April 2002 | pmid = 11931626 | doi = 10.1021/jm010533y }}</ref><ref>Compared with overview in: Fisher, Bruce; Harvey, Richard P.; Champe, Pamela C. (2007). Lippincott's Illustrated Reviews: Microbiology (Lippincott's Illustrated Reviews Series). Hagerstown, MD: Lippincott Williams & Wilkins. {{ISBN|0-7817-8215-5}}. Page 3</ref>
** Damaging the [[Envelope glycoprotein GP120|Docking Glycoprotein gp120]]<ref>{{cite report | title = HIV Sequence Compendium | year = 2017 | vauthors = Foley B, Leitner T, Apetrei C, Hahn B, Mizrachi I, Mullins J, Rambaut A, Wolinsky S, Korber B | publisher = Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, NM, LA-UR 17-25240 }}</ref> (''Stage I-III, VI, VII'')
** Damaging the [[Gp41|Transmembrane Glycoprotein gp41]]<ref>{{cite journal | vauthors = Malashkevich VN, Chan DC, Chutkowski CT, Kim PS | title = Crystal structure of the simian immunodeficiency virus (SIV) gp41 core: conserved helical interactions underlie the broad inhibitory activity of gp41 peptides | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 16 | pages = 9134–9 | date = August 1998 | pmid = 9689046 | pmc = 21304 | doi = 10.1073/pnas.95.16.9134 | bibcode = 1998PNAS...95.9134M | doi-access = free }}</ref> (''Stage I-III, VI, VII'')
** Damaging the virion matrix (''Stage I-III, VI, VII'')
** Damaging the virion Capsid (''Stage I-III, VI, VII'')
** Damaging the Reverse Transcriptase (''Stage I-VII'')
** Damaging the RNA (''Stage I-VII'')

===Blocking replication (Stage V)===
* Insertion into blood chemical or organic compounds which binds to the [[gp120]]. Hypothetically, it can be pieces of the [[CD4]] cell membranes with receptors. Any chemical and organic alternative (with the ability to bind the gp120) of these receptors also can be used.
* Insertion into blood chemical or organic compounds which binds to the receptors of the CD4 cells.

===Biological, chemical or physical approaches to inhibit the process of phases===
* Biological, chemical or physical approach to inhibit the ''Attachment, Penetration, Uncoating, Integration, Replication, Assembling and/or Releasing.''

===Inhibiting the functionality of infected cells (Stage VI-VII)===
Inhibiting the life functions of infected cells:
* Inhibiting the metabolism of infected cells
* Inhibiting the energy exchange of infected cells