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Halothane
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==Society and culture== ===Availability=== It is on the [[WHO Model List of Essential Medicines|World Health Organization's List of Essential Medicines]].<ref name="WHO23rd" /> It is available as a volatile liquid, at 30, 50, 200, and 250 ml per container but in many developed nations is not available having been displaced by newer agents.<ref>{{cite book |title=National formulary of India |edition=4th |location=New Delhi, India |publisher=Indian Pharmacopoeia Commission |date=2011 |page=411}}</ref> It is the only [[inhalational anesthetic]] containing [[bromine]], which makes it [[radiopaque]].<ref>{{cite book | vauthors = Miller AL, Theodore D, Widrich J | title = Inhalational Anesthetic |date=2022 | url = http://www.ncbi.nlm.nih.gov/books/NBK554540/ |id=NBK554540 | series = StatPearls |place=Treasure Island (FL) |publisher=StatPearls Publishing |pmid=32119427 }}</ref> It is colorless and pleasant-smelling, but unstable in light. It is packaged in dark-colored bottles and contains 0.01% [[thymol]] as a stabilizing agent.<ref name = "Gyorfi_1997" /> ===Greenhouse gas=== Owing to the presence of covalently bonded fluorine, halothane absorbs in the [[atmospheric window]] and is therefore a [[greenhouse gas]]. However, it is much less potent than most other [[chlorofluorocarbons]] and [[bromofluorocarbons]] due to its short atmospheric lifetime, estimated at only one year vis-Γ -vis over 100 years for many [[perfluorocarbons]].<ref name="potential">{{cite journal| vauthors = Hodnebrog Γ, Etminan M, Fuglestvedt JS, Marston G, Myhre G, Nielsen CJ, Shine KP, Wallington TJ |title=Global warming potentials and radiative efficiencies of halocarbons and related compounds: A comprehensive review |journal=Reviews of Geophysics |date=24 April 2013 |volume=51 |issue=2 |pages=300β378| doi = 10.1002/rog.20013 | bibcode = 2013RvGeo..51..300H | url = https://centaur.reading.ac.uk/31338/1/ReviewGWP_2nd_rev_v2.pdf }}</ref> Despite its short lifespan, halothane still has a [[global warming potential]] 50 times that of carbon dioxide, although this is over 100 times smaller than the most abundant fluorinated gases, and about 800 times smaller than the GWP of [[sulfur hexafluoride]] over 500 years.<ref name="Updated">{{cite journal | vauthors = Hodnebrog Γ, Aamaas B, Fuglestvedt JS, Marston G, Myhre G, Nielsen CJ, Sandstad M, Shine KP, Wallington TJ | title = Updated Global Warming Potentials and Radiative Efficiencies of Halocarbons and Other Weak Atmospheric Absorbers | journal = Reviews of Geophysics | volume = 58 | issue = 3 | pages = e2019RG000691 | date = September 2020 | doi = 10.1029/2019RG000691 | pmid = 33015672 | pmc = 7518032 | bibcode = 2020RvGeo..5800691H }}</ref> Halothane is believed to make a negligible contribution to [[global warming]].<ref name="potential"/> ===Ozone depletion=== Halothane is an [[ozone depletion|ozone depleting substance]] with an [[Ozone depletion potential|ODP]] of 1.56 and it is calculated to be responsible for 1% of total stratospheric ozone layer depletion.<ref name=Kum2013/><ref name=Lan1999/> Unlike most ozone depleting substances, it is not governed under the [[Montreal Protocol]].<ref>{{cite journal | url=https://agupubs.onlinelibrary.wiley.com/doi/full/10.1002/2014GL062785 | doi=10.1002/2014GL062785 | title=Modern inhalation anesthetics: Potent greenhouse gases in the global atmosphere | date=2015 | journal=Geophysical Research Letters | volume=42 | issue=5 | pages=1606β1611 | bibcode=2015GeoRL..42.1606V | vauthors = Vollmer MK, Rhee TS, Rigby M, Hofstetter D, Hill M, Schoenenberger F, Reimann S }}</ref> {{Clear}}
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