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Inositol trisphosphate
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=== Sea urchin eggs === The [[Egg activation#Fast and slow block to polyspermy|slow block to polyspermy]] in the [[sea urchin]] is mediated by the PIP<sub>2</sub> secondary messenger system. Activation of the binding receptors activates PLC, which cleaves PIP<sub>2</sub> in the egg plasma membrane, releasing IP<sub>3</sub> into the egg cell cytoplasm. IP<sub>3</sub> diffuses to the ER, where it opens Ca<sup>2+</sup> channels.
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