Editing Interferon beta-1a (section)

====Rebif====
Rebif is a disease-modifying drug (DMD) used to treat multiple sclerosis in cases of clinically isolated syndromes as well as relapsing forms of multiple sclerosis and is similar to the interferon beta protein produced by the human body. It is co-marketed by [[Merck Serono]] and [[Pfizer]] in the US under an exception to the [[Orphan Drug Act]]. {{cn|date=October 2020}} It was approved in the European Union in 1998, and in the US in 2002; it has since been approved in more than 90 countries worldwide including Canada and Australia.{{cn|date=October 2020}} EMD Serono has had sole rights to Rebif in the US since January 2016.<ref>{{Cite web|url=https://www.emdgroup.com/en/expertise/neurology-and-immunology.html|title=Neurology & Immunology|website=EMD Group|access-date=2021-08-08|archive-date=2024-04-07|archive-url=https://web.archive.org/web/20240407080938/https://www.emdgroup.com/en/expertise/neurology-and-immunology.html|url-status=live}}</ref><ref>{{Cite press release|url=https://www.prnewswire.com/news-releases/emd-serono-takes-on-exclusive-promotion-of-rebif-interferon-beta-1a-in-the-us-300205988.html|title=EMD Serono Takes on Exclusive Promotion of Rebif (interferon beta-1a) in the US|publisher=EMD Serono|via=PR Newswire|access-date=2021-08-08|archive-date=2023-03-29|archive-url=https://web.archive.org/web/20230329045259/https://www.prnewswire.com/news-releases/emd-serono-takes-on-exclusive-promotion-of-rebif-interferon-beta-1a-in-the-us-300205988.html|url-status=live}}</ref> Rebif is administered via [[subcutaneous injection]].<ref name="Rebif FDA label">{{cite web | title=Rebif- interferon beta-1a kit Rebif Rebidose- interferon beta-1a kit Rebif- interferon beta-1a injection, solution Rebif- interferon beta-1a injection, solution Rebif Rebidose- interferon beta-1a injection, solution | website=DailyMed | date=5 June 2020 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f | access-date=1 October 2020 | archive-date=24 March 2021 | archive-url=https://web.archive.org/web/20210324222529/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c6fcb5d2-8fcd-44fa-a838-b84ee5f44f0f | url-status=live }}</ref>