Editing Interstate 81 (section)

== Major intersections ==
;Tennessee
* {{jct|country=USA|I|40}} near [[Dandridge, Tennessee|Dandridge]], northeast of [[Knoxville, Tennessee|Knoxville]]
* {{jct|country=USA|I|26|US|23}} between the [[Tri-Cities, Tennessee|Tri-Cities]]
;Virginia
* {{jct|country=USA|I|381}} in [[Bristol, Virginia|Bristol]]
*{{jct|country=USA|US|11}} several times
* {{jct|country=USA|I|77}} in [[Wytheville, Virginia|Wytheville]]; concurrent from Wytheville to [[Fort Chiswell, Virginia|Fort Chiswell]].
* {{jct|country=USA|Future|73|I|581|US|220}} in [[Roanoke, Virginia|Roanoke]]
* {{jct|country=USA|I|64}} in [[Lexington, Virginia|Lexington]]; concurrent through [[Staunton, Virginia|Staunton]].
* {{jct|country=USA|US|33}} in [[Harrisonburg, Virginia|Harrisonburg]]
* {{jct|country=USA|I|66}} in [[Middletown, Virginia|Middletown]]
* {{jct|country=USA|US|17|US|50|US|522}} in [[Winchester, Virginia|Winchester]]
;Maryland
* {{jct|country=USA|I|70}} in [[Hagerstown, Maryland|Hagerstown]]
* {{jct|country=USA|US|40}} in Hagerstown
;Pennsylvania
*{{Jct|state=PA|US|11|I-Toll|76|PATP}} in [[Middlesex Township, Cumberland County, Pennsylvania|Middlesex Township]] (near [[Carlisle, Pennsylvania|Carlisle]])
* {{jct|state=PA|PA|581}} in [[Mechanicsburg, Pennsylvania|Mechanicsburg]]
* {{jct|country=USA|US|22|US|322}} in [[Harrisburg, Pennsylvania|Harrisburg]]. I-81/US 322 concurrent throughout Harrisburg.
* {{jct|country=USA|I|83|US|322}} in Harrisburg
* {{jct|country=USA|I|78}} near [[Jonestown, Lebanon County, Pennsylvania|Jonestown]]
* {{jct|country=USA|I|80}} near [[Hazleton, Pennsylvania|Hazleton]]
* {{jct|country=USA|I|476}} in [[Dupont, Pennsylvania|Dupont]] (near [[Pittston, Pennsylvania|Pittston]])
* {{jct|country=USA|I|84|dab1=Pennsylvania–Massachusetts|I|380|dab2=Pennsylvania|US|6}} in [[Dunmore, Pennsylvania|Dunmore]] (near [[Scranton, Pennsylvania|Scranton]])
* {{jct|country=USA|I|476|US|6|US|11}} in [[Clarks Summit, Pennsylvania|Clarks Summit]]
;New York
* {{jct|state=NY|I|86|SR|17|dab1=Pennsylvania–New York}} in [[Binghamton, New York|Binghamton]]
* {{jct|country=USA|I|88|dab1=New York}} in Binghamton
* {{jct|country=USA|I|481}} in [[Syracuse, New York|Syracuse]]
* {{jct|country=USA|I|690}} in downtown Syracuse
* {{jct|country=USA|I|90}} in [[North Syracuse, New York|North Syracuse]]
* {{jct|country=USA|I|781}} in [[Watertown, New York|Watertown]]
* {{jct|province=ON|ON|137|ON|401|to2=yes}}; freeway ends at Canada–US border ([[Thousand Islands Bridge]])
<ref name=randmcnally>{{cite book |author = Rand McNally |year = 2014 |title = The Road Atlas |edition = Walmart |location = Chicago |publisher = Rand McNally |pages = 46, 71, 87–89, 95, 106–107, 112|isbn = 978-0-528-00771-2}}</ref>