Editing Malignancy (section)

===Hyperthermia===
Malignancy can be treated through the use of hyperthermia by applying either surgical perfusion or interstitial techniques to the body.<ref name="Christophi_1998">{{cite journal | vauthors = Christophi C, Winkworth A, Muralihdaran V, Evans P | title = The treatment of malignancy by hyperthermia | journal = Surgical Oncology | volume = 7 | issue = 1–2 | pages = 83–90 | date = 1998 | pmid = 10421511 | doi = 10.1016/s0960-7404(99)00007-9 }}</ref> The use of this treatment type largely depends on the fact that malignant and normal cells have differing responses to the energy source used.<ref name="Christophi_1998" /> This dependency is due to the intracellular changes which occur during hyperthermia; as the [[nucleic acids]], [[cell membrane]] and [[cytoskeleton]] within each cell is affected indirectly and/or through multiple pathways.<ref name="Christophi_1998" /> The combination of these intracellular changes means there is no specific target of cell death in the hyperthermic process.<ref name="Christophi_1998" />