Editing Melissa McCarthy (section)

===Film===
{| class="wikitable sortable"
|-
! Year
! Film
! Role
! class="unsortable" |Notes
|-
| 1998
| ''God''
| Margaret
| Short film
|-
| 1999
| ''[[Go (1999 film)|Go]]''
| Sandra
|
|-
| rowspan=4| 2000
| ''[[Charlie's Angels (2000 film)|Charlie's Angels]]''
| Doris
| 
|-
| ''[[Drowning Mona]]''
| Shirley
|
|-
| ''Auto Motives''
| Tonnie
| Short film
|-
| ''[[Disney's The Kid]]''
| Sky King Waitress
|
|-
| rowspan=3| 2002
| ''[[Pumpkin (film)|Pumpkin]]''
| Cici Pinkus
|
|-
| ''{{sortname|The|Third Wheel|dab=film}}''
| Marilyn
|
|-
| ''[[White Oleander (film)|White Oleander]]''
| Paramedic
|
|-
| rowspan=3| 2003
| ''{{sortname|The|Life of David Gale}}''
| Nico the Goth Girl
|
|-
| ''[[Chicken Party]]''
| Tot Wagner
|
|-
| ''[[Charlie's Angels: Full Throttle]]''
| Woman at Crime Scene
| Uncredited 
|-
| rowspan=3| 2007
| ''[[Cook Off!]]''
| Amber Strang
| 
|-
| ''{{sortname|The|Nines}}''
| Margaret / Melissa / Mary
|
|-
| ''The Captain''
| Fran
| Short film
|-
| rowspan=2| 2008
| ''[[Just Add Water (film)|Just Add Water]]''
| Selma
|
|-
| ''[[Pretty Ugly People]]''
| Becky
|
|-
| rowspan=2| 2010
| ''{{sortname|The|Back-up Plan}}''
| Carol
|
|-
| ''[[Life as We Know It (film)|Life as We Know It]]''
| DeeDee
|
|-
| 2011
| ''[[Bridesmaids (2011 film)|Bridesmaids]]''
| Megan Price
|
|-
| 2012
| ''[[This Is 40]]''
| Catherine
|
|-
| rowspan=3| 2013
| ''[[Identity Thief]]''
| Diana / Dawn Budgie
|
|-
| ''[[The Hangover Part III]]''
| Cassy
|
|-
| ''[[The Heat (film)|The Heat]]''
| Detective Shannon Mullins
|
|-
| rowspan=2| 2014
| ''[[Tammy (film)|Tammy]]''
| Tammy Banks
| Also screenwriter and producer
|-
| ''[[St. Vincent (film)|St. Vincent]]''
| Maggie Bronstein
|
|-
| 2015
| ''[[Spy (2015 film)|Spy]]''
| Susan Cooper
|
|-
| rowspan=3| 2016
| ''[[The Boss (2016 film)|The Boss]]''
| Michelle Darnell
| Also screenwriter and producer 
|-
| ''[[Central Intelligence]]''
| Darla McGuckian
| Cameo
|-
| ''[[Ghostbusters (2016 film)|Ghostbusters]]''
| Dr. Abigail "Abby" Yates
|
|-
| rowspan=3| 2018
| ''[[Life of the Party (2018 film)|Life of the Party]]''
| Deanna Miles
| Also screenwriter and producer
|-
| ''[[The Happytime Murders]]''
| Detective Connie Edwards
| Also producer
|-
| ''[[Can You Ever Forgive Me?]]''
| [[Lee Israel|Leonore "Lee" Israel]]
|
|-
| 2019
| ''[[The Kitchen (2019 film)|The Kitchen]]''
| Kathy Brennan
|
|-
| 2020
| ''[[Superintelligence (film)|Superintelligence]]''
| Carol Vivian Peters
| rowspan="2" | Also producer
|-
| rowspan=2| 2021
| ''[[Thunder Force (film)|Thunder Force]]''
| Lydia Berman / The Hammer
|-
| ''[[The Starling]]''
| Lilly Maynard
|
|-
| 2022
| ''[[Thor: Love and Thunder]]''
| [[Hela (character)|Hela]] actress
| Cameo
|-
| rowspan=2|2023
| ''[[The Little Mermaid (2023 film)|The Little Mermaid]]''
| [[Ursula (The Little Mermaid)|Ursula]]
| 
|-
| ''[[Genie (2023 film)|Genie]]''
| Flora
| Also executive producer
|-
| 2024
| ''[[Unfrosted]]''
| Donna Stankowski
|
|-
| 2027
| ''[[Margie Claus]]''
| Margie Claus
| Voice; also producer
|}