Editing Memory B cell (section)

=== Germinal center independent memory B cells ===
This subset of cells differentiates from activated B cells into memory B cells before entering the germinal center. B cells that have a high level of interaction with T<sub>FH</sub> within the B cell follicle have a higher propensity of entering the germinal center. The B cells that develop into memory B cells independently from germinal centers likely experience CD40 and cytokine signaling from T cells.<ref name=":3"/> Class switching can still occur prior to interaction with the germinal center, while somatic hypermutation only occurs after interaction with the germinal center.<ref name=":3" /> The lack of somatic hypermutation is hypothesized to be beneficial; a lower level of affinity maturation means that these memory B cells are less specialized to a specific antigen and may be able to recognize a wider range of antigens.<ref name=":4" /><ref>{{cite journal | vauthors = Pupovac A, Good-Jacobson KL | title = An antigen to remember: regulation of B cell memory in health and disease | journal = Current Opinion in Immunology | volume = 45 | pages = 89–96 | date = April 2017 | pmid = 28319732 | pmc = 7126224 | doi = 10.1016/j.coi.2017.03.004 | series = Lymphocyte development and activation * Tumour immunology }}</ref><ref name=":3"/>

'''T-independent memory B cells'''

T-independent memory B cells are a subset called B1 cells. These cells generally reside in the peritoneal cavity. When reintroduced to antigen, some of these B1 cells can differentiate into memory B cells without interacting with a T cell.<ref name=":3"/> These B cells produce IgM antibodies to help clear infection.<ref>{{cite journal | vauthors = Montecino-Rodriguez E, Dorshkind K | title = B-1 B cell development in the fetus and adult | journal = Immunity | volume = 36 | issue = 1 | pages = 13–21 | date = January 2012 | pmid = 22284417 | pmc = 3269035 | doi = 10.1016/j.immuni.2011.11.017 }}</ref>

'''T-bet memory B cells'''

T-bet B cells are a subset that have been found to express the transcription factor T-bet. T-bet is associated with class switching. T-bet B cells are also thought to be important in immune responses against intracellular bacterial and viral infections.<ref>{{cite journal | vauthors = Knox JJ, Myles A, Cancro MP | title = T-bet<sup>+</sup> memory B cells: Generation, function, and fate | journal = Immunological Reviews | volume = 288 | issue = 1 | pages = 149–160 | date = March 2019 | pmid = 30874358 | pmc = 6626622 | doi = 10.1111/imr.12736 }}</ref>