Editing Methylphenidate (section)

===Addiction and dependence===
Methylphenidate is a stimulant with an addiction liability and dependence liability similar to [[amphetamine]]. It has moderate liability among [[addictive drug]]s;<ref name="pmid15014637">{{cite journal | vauthors = Morton WA, Stockton GG | title = Methylphenidate Abuse and Psychiatric Side Effects | journal = Primary Care Companion to the Journal of Clinical Psychiatry | volume = 2 | issue = 5 | pages = 159–164 | date = October 2000 | pmid = 15014637 | pmc = 181133 | doi = 10.4088/PCC.v02n0502 }}</ref><ref name="MPH - addiction" /> accordingly, [[addiction]] and [[psychological dependence]] are possible and likely when methylphenidate is used as a recreational drug.<ref name="MPH - addiction" /> When used above the medical dose range, stimulants are associated with the development of [[stimulant psychosis]].<ref>{{cite journal | vauthors = Auger RR, Goodman SH, Silber MH, Krahn LE, Pankratz VS, Slocumb NL | title = Risks of high-dose stimulants in the treatment of disorders of excessive somnolence: A case-control study | journal = Sleep | volume = 28 | issue = 6 | pages = 667–672 | date = June 2005 | pmid = 16477952 | doi = 10.1093/sleep/28.6.667 | doi-access = free }}</ref>

==== Biomolecular mechanisms ====
{{further|Addiction#Biomolecular mechanisms}}
Methylphenidate has the potential to induce [[euphoria]] due to its [[pharmacodynamic]] effect (i.e., [[dopamine reuptake inhibitor|dopamine reuptake inhibition]]) in the brain's [[reward system]]. At therapeutic doses, ADHD stimulants do not sufficiently activate the reward system; consequently, when taken as directed in doses that are commonly prescribed for the treatment of ADHD, methylphenidate use lacks the capacity to cause an [[addiction]].<ref name="MPH - addiction">{{cite book |vauthors=Malenka RC, Nestler EJ, Hyman SE |veditors=Sydor A, Brown RY | year = 2009 | chapter = Chapter&nbsp;15: Reinforcement and addictive disorders | title = Molecular Neuropharmacology: A foundation for clinical neuroscience | publisher = McGraw-Hill Medical | location = New York | isbn = 978-0-07-148127-4 | page = 368 | edition = 2nd}}</ref>