Editing Mitochondrial matrix (section)

=== Urea cycle ===
The first two steps of the urea cycle take place within the mitochondrial matrix of liver and kidney cells. In the first step [[ammonia]] is converted into [[carbamoyl phosphate]] through the investment of two ATP molecules. This step is facilitated by [[carbamoyl phosphate synthetase I]]. The second step facilitated by [[ornithine transcarbamylase]] converts [[carbamoyl phosphate]] and [[ornithine]] into [[citrulline]]. After these initial steps the urea cycle continues in the inner membrane space until ornithine once again enters the matrix through a transport channel to continue the first to steps within matrix.<ref>{{Cite journal|last1=Tuchman|first1=Mendel|last2=Plante|first2=Robert J.|date=1995-01-01|title=Mutations and polymorphisms in the human ornithine transcarbamylase gene: Mutation update addendum|journal=Human Mutation|language=en|volume=5|issue=4|pages=293–295|doi=10.1002/humu.1380050404|issn=1098-1004|pmid=7627182|s2cid=2951786 |doi-access=free}}</ref>