Editing Monoamine transporter (section)

===Depression===
It has been observed that the pathology of depression involves dysfunction of monoamine neurotransmitter circuits in the CNS, particularly of serotonin and norepinephrine.  [[Selective serotonin reuptake inhibitors]] (SSRIs) are the most widely used antidepressant and include [[fluoxetine]] (Prozac), [[citalopram]] (Celexa), and [[fluvoxamine]] (Luvox).  These drugs inhibit the reuptake of serotonin from the extracellular space into the synaptic terminal by selectively inhibiting SERT.  It has been recently observed that serotonin, norepinephrine, and dopamine may all be involved in depression.  Therefore, drugs such as [[venlafaxine]] and [[paroxetine]] are being used as effective antidepressants that selectively inhibit both SERT and NET.<ref name=Nemeroff>{{cite journal|last=Nemeroff|first=Charles B.|author2=Michael J. Owens|title=Treatment of mood disorders|doi=10.1038/nn943 |pmid=12403988|journal=Nature Neuroscience|date=October 2002|pages=1068–1070|volume=5|s2cid=35112132}}</ref>  The [[tricyclic antidepressant]] [[desipramine]] is an antidepressant drug that is a relatively selective inhibitor of NE uptake.  Studies of inhibition of NET correlate with antidepressant activity.<ref name=Reith>{{cite book|title=Neurotransmitter Transporters|year=1997|publisher=Humana Press Inc.|isbn=0-89603-372-4|author=Maarten E. A. Reith|author-link=Role of Axonal and Somatodendritic Monoamine Transporters in Action of Uptake Blockers|author2=Nian-Hang Chen|editor=Maarten E. A. Reith}}</ref>