Editing Multiple sclerosis (section)

=== Immune dysregulation ===
Failure of both central and peripheral nervous system clearance of autoreactive immune cells is implicated in MS development.<ref name="Ward 988–1005"/> The thymus is responsible for the immune system's central tolerance, where autoreactive T-cells are killed without being released into circulation. A similar mechanism kills autoreactive B-cells in the bone marrow. Some autoreactive T-cells & B-cells may escape these defense mechanisms, which is where peripheral immune tolerance defenses take action by preventing them from causing disease. However, these additional lines of defense can still fail.<ref name="Ward 988–1005"/><ref name="McGinley_2021"/> Further detail on immune dysregulation's contribution to MS risk is provided in the [[Multiple sclerosis#Pathophysiology|pathophysiology]] section of this article as well as the standalone article on the [[Pathophysiology of multiple sclerosis|pathophysiology of MS]].