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Nerve agent
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===Carbamates=== Contrary to some claims,<ref>{{Cite web|url= https://www.theguardian.com/uk-news/2018/mar/13/novichok-nerve-agents-russia-salisbury-spy|title= Novichok nerve agents – what are they?|last= Sample|first= Ian | name-list-style = vanc |date= 2018-03-13|website= the Guardian|language= en|archive-url= https://web.archive.org/web/20180318035538/http://www.theguardian.com/uk-news/2018/mar/13/novichok-nerve-agents-russia-salisbury-spy|archive-date= 2018-03-18|url-status= live|access-date= 2018-03-19}}</ref> not all nerve agents are [[organophosphate]]s. The starting compound studied by the United States was the [[carbamate]] EA-1464, of notorious toxicity.<ref name=":6">SUMMARY OF MAJOR EVENTS and PROBLEMS. United States Army Chemical Corps (U). FISCAL YEAR 1960. p-116</ref> Compounds similar in structure and effect to EA-1464 formed a large group, including compounds such as [[EA-3990]] and [[EA-4056]].<ref name=":6" /> The Family Practice Notebook claims carbamate-based nerve agents can be three times as toxic as VX.<ref>{{Cite web |title=Nerve Agent Exposure |url=https://fpnotebook.com/ER/Toxin/NrvAgntExpsr.htm |access-date=2023-07-09 |website=fpnotebook.com}}</ref> Both the United States<ref name=red":4">{{Cite book|title= Handbook of chemical and biological warfare agents | first = D Hank | last = Ellison | name-list-style = vanc |date= 2008|publisher= CRC Press | isbn = 978-0-8493-1434-6 | edition = 2nd | location = Boca Raton | oclc = 82473582 }}</ref> and the Soviet Union<ref>{{cite journal |url= http://archiv.uni-nke.hu/downloads/aarms/docs/Volume6/Issue1/pdf/15vasa.pdf |archive-url= https://web.archive.org/web/20180314042412/http://archiv.uni-nke.hu/downloads/aarms/docs/Volume6/Issue1/pdf/15vasa.pdf |url-status= dead |archive-date= 2018-03-14 |first1= Györgyi |last1= Vásárhelyi |first2= László |last2= Földi |name-list-style= vanc |title= History of Russia's chemical weapons |journal= AARMS |date= 2007 |volume= 6 |issue= 1 |pages= 135–146 }}</ref> developed carbamate-based nerve agents during the [[Cold War]]. Carbamate-based nerve agents are sometimes grouped in academic literature with Fourth Generation Novichok agents, as they were added to the CWC schedule on banned agents at the same time,<ref>{{Cite web |title=New nerve agents added to Chemical Weapons Convention |url=https://cen.acs.org/policy/chemical-weapons/New-nerve-agents-added-Chemical-Weapons-Convention/97/web/2019/12 |access-date=2023-07-09 |website=cen.acs.org}}</ref> despite their significant differences in chemical makeup and mechanisms of action.<ref name=":7">{{cite journal |last1=Palermo |first1=Giulia |last2=Kovarik |first2=Zrinka |last3=Hotchkiss |first3=Peter J. |title=Newly scheduled carbamate compounds: A synopsis of their properties and development, and considerations for the scientific community |journal=Toxicology |date=October 2022 |volume=480 |pages=153322 |doi=10.1016/j.tox.2022.153322 |pmid=36115648 |bibcode=2022Toxgy.48053322P }}</ref> Carbamate-based nerve agents have been identified as Schedule 1 Nerve Agents,<ref name=":7" /> the highest classification possible under the CWC, reserved for agents with no identified alternate use, and those that can cause the most harm.<ref>{{Cite web |title=Annex on Chemicals |url=https://www.opcw.org/chemical-weapons-convention/annexes/annex-chemicals/annex-chemicals |access-date=2023-07-09 |website=OPCW |language=en}}</ref>
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