Editing Paradoxical reaction (section)

=== Naltrexone ===
[[Naltrexone]] blocks the opioid receptors, acting opposite to most opioid pain medications.<ref>{{Citation |last=Wright |first=Tricia E. |title=Pharmacotherapy for Opioid Use Disorders in Special Populations |date=September 2020 |url=http://dx.doi.org/10.1093/med/9780190920197.003.0011 |work=Substance Use Disorders |pages=185–202 |publisher=Oxford University Press |doi=10.1093/med/9780190920197.003.0011 |isbn=978-0-19-092019-7 |access-date=2023-01-15|url-access=subscription }}</ref> It can be used to negate the effects of opioid painkillers. At doses around one-tenth of the typical dose, naltrexone has been used for pain relief. [[Low-dose naltrexone]] is believed to have an anti-inflammatory effect. This is an off-label use and not widely accepted by the medical and scientific community.<ref>{{Cite journal |last1=Younger |first1=Jarred |last2=Parkitny |first2=Luke |last3=McLain |first3=David |date=2014-02-15 |title=The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain |url=http://dx.doi.org/10.1007/s10067-014-2517-2 |journal=Clinical Rheumatology |volume=33 |issue=4 |pages=451–459 |doi=10.1007/s10067-014-2517-2 |pmid=24526250 |pmc=3962576 |s2cid=16191753 |issn=0770-3198}}</ref>