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Pyramidal cell
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===Firing classifications=== Pyramidal neurons have been classified into different subclasses based upon their firing responses to 400-1000 millisecond current pulses. These classification are RSad, RSna, and IB neurons. ====RSad==== RSad pyramidal neurons, or adapting regular [[Biological neuron model|spiking neuron]]s, fire with individual [[action potential]]s (APs), which are followed by a [[Hyperpolarization (biology)|hyperpolarizing]] afterpotential. The afterpotential increases in duration which creates [[Action potential|spike frequency]] [[Neural adaptation|adaptation]] (SFA) in the neuron.<ref name = "Frances">{{cite journal | vauthors = Franceschetti S, Sancini G, Panzica F, Radici C, Avanzini G | title = Postnatal differentiation of firing properties and morphological characteristics in layer V pyramidal neurons of the sensorimotor cortex | journal = Neuroscience | volume = 83 | issue = 4 | pages = 1013β1024 | date = April 1998 | pmid = 9502243 | doi = 10.1016/S0306-4522(97)00463-6 | s2cid = 6986307 }}</ref> ====RSna==== RSna pyramidal neurons, or non-adapting regular spiking neurons, fire a train of action potentials after a pulse. These neurons show no signs of adaptation.<ref name="Frances" /> ====IB==== IB pyramidal neurons, or intrinsically bursting neurons, respond to [[Threshold potential|threshold]] pulses with a burst of two to five rapid action potentials. IB pyramidal neurons show no adaptation.<ref name="Frances" />
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