Editing Rapid sequence induction (section)

===== Depolarizing blockers =====
* [[Suxamethonium|Succinylcholine]] – This drug has rapid onset of action and fast duration. Its dosages are between 1 and 2&nbsp;mg/kg body weight with common dosage of 100&nbsp;mg. The drug can only be kept under room temperature for 14 days. Therefore, for longer shelf life, it has to be kept under temperatures from {{convert|3.3|C|F}} to {{convert|8.7|C|F}}.  When the intravenous access is not obtainable, the 3 to 4&nbsp;mg/kg of intramuscular doses can be given (usual dose of 300&nbsp;mg). However, duration of onset will be delayed to 3 to 4 minutes. Repetitive dosages of succinylcholine are discouraged to prevent vagal stimulation which leads to bradycardia.<ref name="Joanna 2014"/> There are many absolute contraindications to succinylcholine including recent [[stroke]], [[hyperkalemia]], [[burn]] patients, immobilized patients (i.e. wheelchair bound).<ref>{{Citation |last1=Cook |first1=Danielle |title=Neuromuscular Blockade |date=2022 |url=http://www.ncbi.nlm.nih.gov/books/NBK538301/ |work=StatPearls |place=Treasure Island (FL) |publisher=StatPearls Publishing |pmid=30855885 |access-date=2022-11-10 |last2=Simons |first2=David J.}}</ref> This is due to the upregulation of [[Neuromuscular junction|neuromuscular junctions]].<ref name=":9" /> Additionally, cautions should be used in patients with reduced serum [[Butyrylcholinesterase|plasma cholinesterase]], as this is how the drug removed from the body.<ref name=":10">{{Citation |last1=Hager |first1=Heather H. |title=Succinylcholine Chloride |date=2022 |url=http://www.ncbi.nlm.nih.gov/books/NBK499984/ |work=StatPearls |place=Treasure Island (FL) |publisher=StatPearls Publishing |pmid=29763160 |access-date=2022-11-10 |last2=Burns |first2=Bracken}}</ref> In patients with decreased [[Butyrylcholinesterase|plasma cholinesterase]], the paralysis from succinylcholine can increase significantly in duration.<ref name=":10" /> A common side effect of succinylcholine includes [[Myalgia|myalgias]] after neuromuscular induced [[Fasciculation|fasciculations]] upon induction.<ref name=":10" />