Editing Reperfusion injury (section)

=== Metformin ===
A series of 2009 studies published in the Journal of Cardiovascular Pharmacology suggest that [[Metformin]] may prevent cardiac reperfusion injury by inhibition of [[Electron transport chain|Mitochondrial Complex I]] and the opening of MPT pore and  in rats.<ref>{{cite journal |last1=Paiva |first1=Marta |last2=Riksen |first2=Niels P |last3=Davidson |first3=Sean M |last4=Hausenloy |first4=Derek J |last5=Monteiro |first5=Pedro |last6=Gonçalves |first6=Lino |last7=Providência |first7=Luís |last8=Rongen |first8=Gerard A |last9=Smits |first9=Paul |last10=Mocanu |first10=Mihaela M |last11=Yellon |first11=Derek M |title=Metformin Prevents Myocardial Reperfusion Injury by Activating the Adenosine Receptor |journal=Journal of Cardiovascular Pharmacology |date=May 2009 |volume=53 |issue=5 |pages=373–378 |doi=10.1097/FJC.0b013e31819fd4e7 |pmid=19295441 |s2cid=21161059 }}</ref><ref>{{cite journal |last1=Bhamra |first1=Gurpreet S. |last2=Hausenloy |first2=Derek J. |last3=Davidson |first3=Sean M. |last4=Carr |first4=Richard D. |last5=Paiva |first5=Marta |last6=Wynne |first6=Abigail M. |last7=Mocanu |first7=Mihaela M. |last8=Yellon |first8=Derek M. |title=Metformin protects the ischemic heart by the Akt-mediated inhibition of mitochondrial permeability transition pore opening |journal=Basic Research in Cardiology |date=May 2008 |volume=103 |issue=3 |pages=274–284 |doi=10.1007/s00395-007-0691-y |pmid=18080084 |s2cid=28815693 }}</ref>